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    Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 192775, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnh6provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily H (eag-related), member 6provided by MGI
    Primary source
    MGI:MGI:2684139
    See related
    Ensembl:ENSMUSG00000001901 AllianceGenome:MGI:2684139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    m-erg2
    Summary
    Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; retina; and skin. Used to study glucose metabolism disease. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnh6 in Genome Data Viewer
    Location:
    11 E1; 11 68.87 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105898871..105926421)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106008044..106035595)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme 3 Neighboring gene STARR-positive B cell enhancer ABC_E43 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (3) 

    General gene information

    Markers

    Clone Names

    • MGC129366

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in membrane repolarization during cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate by cardiac conduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily H member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037712.2NP_001032801.1  potassium voltage-gated channel subfamily H member 6

      See identical proteins and their annotated locations for NP_001032801.1

      Status: VALIDATED

      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS25545.1
      UniProtKB/TrEMBL
      B1AR82, Q32ME0
      Related
      ENSMUSP00000001965.8, ENSMUST00000001965.14
      Conserved Domains (6) summary
      COG0664
      Location:588701
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:594705
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:41132
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:296520
      Ion_trans; Ion transport protein
      pfam07885
      Location:463517
      Ion_trans_2; Ion channel
      pfam13426
      Location:29132
      PAS_9; PAS domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105898871..105926421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532554.4XP_006532617.1  potassium voltage-gated channel subfamily H member 6 isoform X4

      UniProtKB/TrEMBL
      M0QW64
      Related
      ENSMUSP00000137675.2, ENSMUST00000145539.2
      Conserved Domains (2) summary
      PLN03192
      Location:259698
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam13426
      Location:29132
      PAS_9; PAS domain
    2. XM_006532550.4XP_006532613.1  potassium voltage-gated channel subfamily H member 6 isoform X1

      UniProtKB/TrEMBL
      B1AR82
      Conserved Domains (2) summary
      PLN03192
      Location:259698
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam13426
      Location:29132
      PAS_9; PAS domain
    3. XM_030245696.2XP_030101556.1  potassium voltage-gated channel subfamily H member 6 isoform X2

      UniProtKB/TrEMBL
      B1AR82
      Conserved Domains (2) summary
      PLN03192
      Location:259698
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam13426
      Location:29132
      PAS_9; PAS domain
    4. XM_006532551.5XP_006532614.1  potassium voltage-gated channel subfamily H member 6 isoform X3

      UniProtKB/TrEMBL
      B1AR82
      Conserved Domains (1) summary
      PLN03192
      Location:136575
      PLN03192; Voltage-dependent potassium channel; Provisional

    RNA

    1. XR_004936864.1 RNA Sequence

    2. XR_004936865.1 RNA Sequence

    3. XR_388374.4 RNA Sequence

    4. XR_004936866.1 RNA Sequence

    5. XR_003949358.2 RNA Sequence

    6. XR_003949357.2 RNA Sequence

    7. XR_004936867.1 RNA Sequence

    8. XR_388373.4 RNA Sequence

    9. XR_004936862.1 RNA Sequence

    10. XR_003949355.1 RNA Sequence

    11. XR_004936860.1 RNA Sequence

    12. XR_004936861.1 RNA Sequence

    13. XR_001779926.3 RNA Sequence

    14. XR_004936863.1 RNA Sequence