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    Cd53 CD53 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd53provided by MGI
    Official Full Name
    CD53 antigenprovided by MGI
    Primary source
    MGI:MGI:88341
    See related
    Ensembl:ENSMUSG00000040747 AllianceGenome:MGI:88341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox-44; Tspan25
    Summary
    Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 20.6), mammary gland adult (RPKM 14.1) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cd53 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106666177..106697465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106758861..106790149, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene choline/ethanolaminephosphotransferase 1 Neighboring gene STARR-seq mESC enhancer starr_08650 Neighboring gene STARR-positive B cell enhancer ABC_E6102 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene STARR-seq mESC enhancer starr_08651 Neighboring gene STARR-seq mESC enhancer starr_08652 Neighboring gene STARR-seq mESC enhancer starr_08653 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10205 Neighboring gene STARR-seq mESC enhancer starr_08654 Neighboring gene olfactory receptor family 11 subfamily I member 1 Neighboring gene predicted gene, 35507 Neighboring gene STARR-seq mESC enhancer starr_08655

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NOT involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of myoblast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in immunological synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leukocyte surface antigen CD53
    Names
    cell surface glycoprotein CD53

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007651.3NP_031677.1  leukocyte surface antigen CD53

      See identical proteins and their annotated locations for NP_031677.1

      Status: VALIDATED

      Source sequence(s)
      AA177409, AC117255, AK160326
      Consensus CDS
      CCDS17728.1
      UniProtKB/Swiss-Prot
      Q61451, Q61721
      UniProtKB/TrEMBL
      Q3TV80, Q3U0W1
      Related
      ENSMUSP00000035781.9, ENSMUST00000038845.10
      Conserved Domains (2) summary
      cd03164
      Location:104186
      CD53_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:9210
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106666177..106697465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)