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    Srsf1 serine and arginine-rich splicing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 110809, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Srsf1provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 1provided by MGI
    Primary source
    MGI:MGI:98283
    See related
    Ensembl:ENSMUSG00000018379 AllianceGenome:MGI:98283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asf; Sf2; Sfrs1; 1110054N12Rik; 5730507C05Rik; 6330415C05Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 77.9), CNS E14 (RPKM 62.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf1 in Genome Data Viewer
    Location:
    11 C; 11 52.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87937325..87944583)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88046499..88053757)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 2 Neighboring gene predicted gene, 38610 Neighboring gene STARR-positive B cell enhancer ABC_E9835 Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation. Shimoni-Sebag A, et al. Carcinogenesis, 2013 Nov. PMID 23843040
    2. SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal. Yu T, et al. Dev Cell, 2022 Mar 14. PMID 35202586, Free PMC Article
    3. SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development. Qi Z, et al. Sci Adv, 2021 Apr. PMID 33863728, Free PMC Article
    4. Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity. Juarez I, et al. Front Immunol, 2022. PMID 36189299, Free PMC Article
    5. Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice. Liu Y, et al. Stem Cell Reports, 2020 Oct 13. PMID 32888503, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-kappaB axis.
      Title: LncRNA MAAMT facilitates macrophage recruitment and proinflammatory activation and exacerbates autoimmune myocarditis through the SRSF1/NF-κB axis.
    2. SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing.
      Title: SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing.
    3. Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion.
      Title: Truncated Dyrk1A aggravates neuronal apoptosis by inhibiting ASF-mediated Bcl-x exon 2b inclusion.
    4. Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.
      Title: Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice.
    5. SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
      Title: SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing.
    6. Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
      Title: Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression.
    7. Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.
      Title: Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.
    8. SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice.
      Title: SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice.
    9. SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I.
      Title: SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I.
    10. Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
      Title: Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA topoisomerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RS domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables molecular function regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA splicing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to interleukin-17 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interleukin-17-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-17-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 5'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 5'-splice site recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction involved in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 1
    Names
    ASF/SF2
    pre-mRNA-splicing factor SRp30a
    splicing factor, arginine/serine-rich 1 (ASF/SF2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078167.2 → NP_001071635.1  serine/arginine-rich splicing factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001071635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK053674, AK078715, AL593853, CF739274
      Consensus CDS
      CCDS36274.1
      UniProtKB/Swiss-Prot
      Q6PDM2
      Related
      ENSMUSP00000133517.2, ENSMUST00000079866.11
      Conserved Domains (3) summary
      COG0724
      Location:8 → 88
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12597
      Location:17 → 90
      RRM1_SRSF1; RNA recognition motif 1 in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cl17169
      Location:121 → 190
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_173374.4 → NP_775550.2  serine/arginine-rich splicing factor 1 isoform 1

      See identical proteins and their annotated locations for NP_775550.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK053674, AL593853, CF739274
      Consensus CDS
      CCDS36273.1
      UniProtKB/Swiss-Prot
      B2KGJ5, Q3UCH2, Q5SXC5, Q6PDM2, Q8BJV3, Q8C1H9
      Related
      ENSMUSP00000120595.3, ENSMUST00000139129.9
      Conserved Domains (2) summary
      cd12597
      Location:12 → 90
      RRM1_SRSF1; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins
      cd12767
      Location:113 → 196
      RRM2_SRSF1; RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 1 (SRSF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87937325..87944583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_388324.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDM2.3 GenPept UniProtKB/Swiss-Prot:Q6PDM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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