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    Styk1 serine/threonine/tyrosine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 243659, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Styk1provided by MGI
    Official Full Name
    serine/threonine/tyrosine kinase 1provided by MGI
    Primary source
    MGI:MGI:2141396
    See related
    Ensembl:ENSMUSG00000032899 AllianceGenome:MGI:2141396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nok; 9130025L13
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be active in plasma membrane. Is expressed in brain and olfactory epithelium. Orthologous to human STYK1 (serine/threonine/tyrosine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 8.7), colon adult (RPKM 6.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Styk1 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131276096..131330532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131299133..131353836, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene mago homolog B, exon junction complex core component Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131303559-131303777 Neighboring gene STARR-seq mESC enhancer starr_17494 Neighboring gene Y box protein 3 Neighboring gene STARR-positive B cell enhancer mm9_chr6:131338351-131338652 Neighboring gene STARR-seq mESC enhancer starr_17495 Neighboring gene predicted gene, 22362 Neighboring gene STARR-seq mESC enhancer starr_17496 Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function. Wilharm A, et al. Eur J Immunol, 2019 May. PMID 30758858
    2. Styk1 expression is a hallmark of murine NK cells and other NK1.1(+) subsets but is dispensable for NK-cell development and effector functions. Fauteux-Daniel S, et al. Eur J Immunol, 2019 May. PMID 30690705, Free PMC Article
    3. Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Chen Y, et al. Cancer Res, 2005 Dec 1. PMID 16322230
    4. Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice. Yang Y, et al. Biochem Biophys Res Commun, 2022 Oct 20. PMID 35970044
    5. STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking. He J, et al. J Transl Med, 2024 Oct 16. PMID 39415235, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking.
      Title: STYK1 mediates NK cell anti-tumor response through regulating CCR2 and trafficking.
    2. Styk1 expression is specific for NK cells and selected NK-like innate T-cell subsets, but dispensable for their development and function.
      Title: Styk1 is specifically expressed in NK1.1(+) lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.
    3. high Styk1 expression is a hallmark of NK cells and that Styk1 is not essential for NK cell development, activation and antiviral functions.
      Title: Styk1 expression is a hallmark of murine NK cells and other NK1.1(+) subsets but is dispensable for NK-cell development and effector functions.
    4. Point mutations at either Y327 or Y356 dramatically blocked cellular transformation by NOK as examined by colony formation and cellular DNA synthesis.
      Title: Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase STYK1
    Names
    NOK kinase
    mNOK
    novel oncogene with kinase domain
    NP_001398609.1
    NP_001398610.1
    NP_001398611.1
    NP_001398612.1
    NP_001398613.1
    NP_001398614.1
    NP_766479.1
    XP_006506194.1
    XP_006506195.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411680.1 → NP_001398609.1  tyrosine-protein kinase STYK1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326
      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6

    2. NM_001411681.1 → NP_001398610.1  tyrosine-protein kinase STYK1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326
      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6

    3. NM_001411682.1 → NP_001398611.1  tyrosine-protein kinase STYK1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326
      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6

    4. NM_001411683.1 → NP_001398612.1  tyrosine-protein kinase STYK1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326

    5. NM_001411684.1 → NP_001398613.1  tyrosine-protein kinase STYK1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326
      Related
      ENSMUSP00000112900.2, ENSMUST00000121078.2

    6. NM_001411685.1 → NP_001398614.1  tyrosine-protein kinase STYK1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326

    7. NM_172891.3 → NP_766479.1  tyrosine-protein kinase STYK1 isoform a

      See identical proteins and their annotated locations for NP_766479.1

      Status: VALIDATED

      Source sequence(s)
      AC122191, AC148326
      Consensus CDS
      CCDS20604.1
      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6
      Related
      ENSMUSP00000044098.2, ENSMUST00000049150.8
      Conserved Domains (1) summary
      cl21453
      Location:123 → 388
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      131276096..131330532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506131.4 → XP_006506194.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_006506194.1

      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6
      Conserved Domains (1) summary
      cl21453
      Location:123 → 388
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006506132.4 → XP_006506195.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_006506195.1

      UniProtKB/Swiss-Prot
      Q6J9G1, Q8BZH6, Q8BZT1
      UniProtKB/TrEMBL
      B2RWV6
      Conserved Domains (1) summary
      cl21453
      Location:123 → 388
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6J9G1.2 GenPept UniProtKB/Swiss-Prot:Q6J9G1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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