Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntrk2provided by MGI
Official Full Name: neurotrophic tyrosine kinase, receptor, type 2provided by MGI
Primary source: MGI:MGI:97384
See related: Ensembl:ENSMUSG00000055254 AllianceGenome:MGI:97384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
Summary: Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and terminal bouton. Is expressed in several structures, including alimentary system; future brain; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autistic disorder; developmental and epileptic encephalopathy 58; heroin dependence; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 10.3), cortex adult (RPKM 10.2) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 31.2 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (58954363..59281782)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (58806472..59133970)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.
Title: Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling.
TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level.
Title: TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level.
Genetic Dissection of BDNF and TrkB Expression in Glial Cells.
Title: Genetic Dissection of BDNF and TrkB Expression in Glial Cells.
Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-beta/SMAD signaling.
Title: Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling.
Linking Hypothermia and Altered Metabolism with TrkB Activation.
Title: Linking Hypothermia and Altered Metabolism with TrkB Activation.
The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells.
Title: The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells.
Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.
Title: Rab10 regulates the sorting of internalised TrkB for retrograde axonal transport.
Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-beta1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling.
Title: Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-β1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling.
The BDNF-TrkB signaling pathway is partially involved in the neuroprotective effects of hydrogen sulfide in Parkinson's disease.
Title: The BDNF-TrkB signaling pathway is partially involved in the neuroprotective effects of hydrogen sulfide in Parkinson's disease.
The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.
Title: The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Submit: New GeneRIF Correction See all GeneRIFs (273)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Gene trapped (1)
Targeted (23) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI848316 (e-PCR)
- UniSTS:180543

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:260424

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:546906

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:256891

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275894

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275895

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275896

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275897

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275898

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275899

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275900

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275901

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:275902

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:265674

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:265675

Ntrk2 (e-PCR), detects polymorphism
- UniSTS:525564

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor binding	IDA Inferred from Direct Assay more info	PubMed
enables brain-derived neurotrophic factor binding	ISO Inferred from Sequence Orthology more info
enables brain-derived neurotrophic factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables brain-derived neurotrophic factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables brain-derived neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables neurotrophin binding	IDA Inferred from Direct Assay more info	PubMed
enables neurotrophin binding	ISO Inferred from Sequence Orthology more info
enables neurotrophin binding	ISS Inferred from Sequence or Structural Similarity more info
enables neurotrophin receptor activity	ISO Inferred from Sequence Orthology more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to brain-derived neurotrophic factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate secretion	IPI Inferred from Physical Interaction more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mechanoreceptor differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination in peripheral nervous system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuronal action potential propagation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of glucocorticoid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal rod cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BDNF/NT-3 growth factors receptor

Names: neurotrophic tyrosine receptor kinase type 2; trkB tyrosine kinase

NP_001020245.1

EC 2.7.10.1

NP_001269890.1

EC 2.7.10.1

NP_001413233.1

EC 2.7.10.1

NP_001413235.1

EC 2.7.10.1

NP_001413236.1

EC 2.7.10.1

NP_001413237.1

EC 2.7.10.1

NP_001413238.1

EC 2.7.10.1

NP_032771.1

EC 2.7.10.1

XP_006517212.1

EC 2.7.10.1

XP_006517214.1

EC 2.7.10.1

XP_030103049.1

EC 2.7.10.1

XP_036013804.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025074.3 → NP_001020245.1 BDNF/NT-3 growth factors receptor isoform a precursor

See identical proteins and their annotated locations for NP_001020245.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.

Source sequence(s)

AC154755, AC159195

Consensus CDS

CCDS26573.1

UniProtKB/Swiss-Prot

P15209, Q3TUF9, Q80WU0, Q91XJ9

Related

ENSMUSP00000078757.6, ENSMUST00000079828.7

Conserved Domains (5) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

cd05093
Location:531 → 818

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001282961.2 → NP_001269890.1 BDNF/NT-3 growth factors receptor isoform a precursor

See identical proteins and their annotated locations for NP_001269890.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).

Source sequence(s)

AC154755, AC159195

Consensus CDS

CCDS26573.1

UniProtKB/Swiss-Prot

P15209, Q3TUF9, Q80WU0, Q91XJ9

Related

ENSMUSP00000153553.2, ENSMUST00000225488.2

Conserved Domains (5) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

cd05093
Location:531 → 818

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
NM_001426304.1 → NP_001413233.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: VALIDATED

Source sequence(s)

AC159195

UniProtKB/TrEMBL

A0A286YDA0, Q3UHE3
NM_001426306.1 → NP_001413235.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: VALIDATED

Source sequence(s)

AC159195

UniProtKB/TrEMBL

A0A286YDA0, Q3UHE3
NM_001426307.1 → NP_001413236.1 BDNF/NT-3 growth factors receptor isoform b precursor

Status: VALIDATED

Source sequence(s)

AC159195

UniProtKB/TrEMBL

A0A286YDA0, Q3UHE3

Related

ENSMUSP00000105464.3, ENSMUST00000109838.10
NM_001426308.1 → NP_001413237.1 BDNF/NT-3 growth factors receptor isoform c precursor

Status: VALIDATED

Source sequence(s)

AC154755, AC159195

UniProtKB/TrEMBL

A0A286YDA0
NM_001426309.1 → NP_001413238.1 BDNF/NT-3 growth factors receptor isoform c precursor

Status: VALIDATED

Source sequence(s)

AC154755, AC159195

UniProtKB/TrEMBL

A0A286YDA0
NM_008745.4 → NP_032771.1 BDNF/NT-3 growth factors receptor isoform b precursor

See identical proteins and their annotated locations for NP_032771.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC159195

Consensus CDS

CCDS36685.1

UniProtKB/TrEMBL

A0A286YDA0, Q3UHE3

Related

ENSMUSP00000153270.2, ENSMUST00000224259.2

Conserved Domains (6) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

cl02423
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl11960
Location:205 → 283

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

58954363..59281782

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157911.1 → XP_036013804.1 BDNF/NT-3 growth factors receptor isoform X3

UniProtKB/TrEMBL

A0A286YDA0, A0A286YDA3

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_006517149.5 → XP_006517212.1 BDNF/NT-3 growth factors receptor isoform X1

See identical proteins and their annotated locations for XP_006517212.1

UniProtKB/Swiss-Prot

P15209, Q3TUF9, Q80WU0, Q91XJ9

Conserved Domains (5) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

cd05093
Location:531 → 818

PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_030247189.2 → XP_030103049.1 BDNF/NT-3 growth factors receptor isoform X4

UniProtKB/TrEMBL

A0A286YDA0, Q3UHE3

Conserved Domains (6) summary

cd05855
Location:301 → 379

Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

cl02423
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl11960
Location:205 → 283

Ig; Immunoglobulin domain
XM_006517151.5 → XP_006517214.1 BDNF/NT-3 growth factors receptor isoform X3

UniProtKB/TrEMBL

A0A286YDA0, A0A286YDA3

Related

ENSMUSP00000153333.2, ENSMUST00000224402.2

Conserved Domains (7) summary

sd00031
Location:96 → 116

LRR_1; leucine-rich repeat [structural motif]

pfam01462
Location:31 → 60

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:152 → 195

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:205 → 209

Ig; Ig strand A' [structural motif]

cd05855
Location:286 → 379

IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:205 → 283

Ig; Immunoglobulin domain