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    Lpin1 lipin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14245, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lpin1provided by MGI
    Official Full Name
    lipin 1provided by MGI
    Primary source
    MGI:MGI:1891340
    See related
    Ensembl:ENSMUSG00000020593 AllianceGenome:MGI:1891340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    fld; Lipin1
    Summary
    Enables several functions, including histone deacetylase binding activity; peroxisome proliferator activated receptor binding activity; and phosphatidate phosphatase activity. Involved in several processes, including mitochondrial fission; positive regulation of metabolic process; and triglyceride metabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; regulation of fat cell differentiation; and ruffle organization. Located in endoplasmic reticulum; mitochondrial outer membrane; and nuclear membrane. Part of transcription regulator complex. Is active in endoplasmic reticulum membrane. Is expressed in liver; nervous system; olfactory epithelium; and tooth. Used to study lipodystrophy. Orthologous to human LPIN1 (lipin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 79.1), subcutaneous fat pad adult (RPKM 36.4) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lpin1 in Genome Data Viewer
    Location:
    12 A1.1; 12 7.9 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16585670..16697020, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16535669..16653903, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36372 Neighboring gene STARR-seq mESC enhancer starr_31631 Neighboring gene predicted gene, 48606 Neighboring gene STARR-seq mESC enhancer starr_31632 Neighboring gene STARR-seq mESC enhancer starr_31633 Neighboring gene STARR-seq mESC enhancer starr_31635 Neighboring gene STARR-seq mESC enhancer starr_31636 Neighboring gene predicted gene, 53741 Neighboring gene STARR-seq mESC enhancer starr_31639 Neighboring gene STARR-seq mESC enhancer starr_31643 Neighboring gene STARR-positive B cell enhancer ABC_E11503 Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene neurotensin receptor 2 Neighboring gene gene regulated by estrogen in breast cancer protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [Lipin 1 in lipid metabolism]. Ishimoto K. Yakugaku Zasshi, 2011. PMID 21804322
    2. Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Chen Z, et al. Arterioscler Thromb Vasc Biol, 2008 Oct. PMID 18669885, Free PMC Article
    3. The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. Bou Khalil M, et al. J Lipid Res, 2009 Jan. PMID 18769019
    4. Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. Rashid T, et al. EMBO J, 2019 Jan 3. PMID 30420558, Free PMC Article
    5. Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. Schweitzer GG, et al. FASEB J, 2019 Jan. PMID 30028636, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy.
      Title: Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy.
    2. Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
      Title: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1.
    3. Lipin-1 deficiency deteriorates defect of fatty acid beta-oxidation and lipid-related kidney damage in diabetic kidney disease.
      Title: Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
    4. Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
      Title: Lipin1 plays complementary roles in myofibre stability and regeneration in dystrophic muscles.
    5. LPIN1 is a new target gene for essential hypertension.
      Title: LPIN1 is a new target gene for essential hypertension.
    6. Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
      Title: Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations.
    7. Macrophage-Associated Lipin-1 Promotes beta-Oxidation in Response to Proresolving Stimuli.
      Title: Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.
    8. Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
      Title: Myeloid-associated lipin-1 transcriptional co-regulatory activity is atheroprotective.
    9. Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
      Title: Loss of membrane integrity drives myofiber death in lipin1-deficient skeletal muscle.
    10. The middle lipin domain adopts a membrane-binding dimeric protein fold.
      Title: The middle lipin domain adopts a membrane-binding dimeric protein fold.
    Submit: New GeneRIF Correction See all GeneRIFs (88)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • Kiaa0188, mKIAA0188, 4631420P06

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxisome proliferator activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ruffle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in triglyceride mobilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidate phosphatase LPIN1
    Names
    fatty liver dystrophy protein
    NP_001123884.1
    NP_001342527.1
    NP_056578.2
    NP_766538.2
    XP_006515038.1
    XP_006515039.1
    XP_006515040.1
    XP_006515041.1
    XP_006515045.1
    XP_006515046.1
    XP_006515047.1
    XP_006515049.1
    XP_006515050.1
    XP_011242117.1
    XP_030102417.1
    XP_030102419.1
    XP_030102420.1
    XP_036013081.1
    XP_036013082.1
    XP_036013083.1
    XP_036013084.1
    XP_036013085.1
    XP_036013086.1
    XP_036013087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130412.1 → NP_001123884.1  phosphatidate phosphatase LPIN1 isoform a

      See identical proteins and their annotated locations for NP_001123884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. This variant encodes isoform a. Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK009789, AK014526, AK030921, BY127780, BY209929, CK621866, CX205142
      Consensus CDS
      CCDS25823.1
      UniProtKB/TrEMBL
      A0A1Y7VLN4, Q3U3C3, Q8CD95
      Related
      ENSMUSP00000152276.2, ENSMUST00000222989.2
      Conserved Domains (4) summary
      pfam15017
      Location:856 → 885
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:627 → 852
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465 → 555
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. NM_001355598.1 → NP_001342527.1  phosphatidate phosphatase LPIN1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC159631, AK019539
      Consensus CDS
      CCDS25822.1
      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A0R4J0V3, E9QKQ5
      Related
      ENSMUSP00000106696.4, ENSMUST00000111067.10
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660 → 885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498 → 589
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. NM_015763.4 → NP_056578.2  phosphatidate phosphatase LPIN1 isoform b

      See identical proteins and their annotated locations for NP_056578.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform b), compared to isoform a. Isoform b is also known as isoform beta. Variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AK009789, AK014526, BY127780, CK621866, CX205142
      Consensus CDS
      CCDS25822.1
      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A0R4J0V3, E9QKQ5
      Related
      ENSMUSP00000070583.6, ENSMUST00000067124.6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660 → 885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498 → 589
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. NM_172950.3 → NP_766538.2  phosphatidate phosphatase LPIN1 isoform a

      See identical proteins and their annotated locations for NP_766538.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Isoform a is also known as isoform alpha. Variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK009789, AK014526, AK030921, BY127780, CK621866, CX205142
      Consensus CDS
      CCDS25823.1
      UniProtKB/TrEMBL
      A0A1Y7VLN4, Q3U3C3, Q8CD95
      Related
      ENSMUSP00000152466.2, ENSMUST00000221230.2
      Conserved Domains (4) summary
      pfam15017
      Location:856 → 885
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:627 → 852
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465 → 555
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      16585670..16697020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514975.4 → XP_006515038.1  phosphatidate phosphatase LPIN1 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Conserved Domains (4) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:746 → 971
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:237 → 429
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:558 → 631
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. XM_036157191.1 → XP_036013084.1  phosphatidate phosphatase LPIN1 isoform X11

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A0R4J0V3, E9QKQ5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660 → 885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498 → 589
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. XM_006514977.4 → XP_006515040.1  phosphatidate phosphatase LPIN1 isoform X4

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Related
      ENSMUSP00000158955.2, ENSMUST00000238839.2
      Conserved Domains (4) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:720 → 945
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:237 → 429
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:558 → 648
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. XM_030246557.2 → XP_030102417.1  phosphatidate phosphatase LPIN1 isoform X5

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Conserved Domains (4) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:719 → 944
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:237 → 428
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:557 → 647
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    5. XM_006514982.5 → XP_006515045.1  phosphatidate phosphatase LPIN1 isoform X6

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Conserved Domains (3) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:687 → 912
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:525 → 615
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    6. XM_036157189.1 → XP_036013082.1  phosphatidate phosphatase LPIN1 isoform X10

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      Conserved Domains (3) summary
      pfam04571
      Location:21 → 127
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:680 → 905
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:518 → 609
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    7. XM_036157188.1 → XP_036013081.1  phosphatidate phosphatase LPIN1 isoform X9

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      Conserved Domains (3) summary
      pfam04571
      Location:25 → 131
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:684 → 909
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:522 → 613
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    8. XM_036157190.1 → XP_036013083.1  phosphatidate phosphatase LPIN1 isoform X10

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      Conserved Domains (3) summary
      pfam04571
      Location:21 → 127
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:680 → 905
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:518 → 609
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    9. XM_030246559.2 → XP_030102419.1  phosphatidate phosphatase LPIN1 isoform X13

      UniProtKB/TrEMBL
      Q3U3C3, Q8CD95
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:653 → 878
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465 → 538
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    10. XM_036157193.1 → XP_036013086.1  phosphatidate phosphatase LPIN1 isoform X12

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:659 → 884
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:497 → 588
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    11. XM_036157192.1 → XP_036013085.1  phosphatidate phosphatase LPIN1 isoform X11

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A0R4J0V3, E9QKQ5
      Related
      ENSMUSP00000152285.2, ENSMUST00000221297.2
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 107
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:660 → 885
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:498 → 589
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    12. XM_006514978.5 → XP_006515041.1  phosphatidate phosphatase LPIN1 isoform X3

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Conserved Domains (3) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:713 → 938
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:525 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    13. XM_006514976.5 → XP_006515039.1  phosphatidate phosphatase LPIN1 isoform X2

      UniProtKB/TrEMBL
      A0A5F8MPG1
      Conserved Domains (4) summary
      pfam04571
      Location:61 → 166
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:745 → 970
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:237 → 428
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:557 → 630
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    14. XM_006514987.5 → XP_006515050.1  phosphatidate phosphatase LPIN1 isoform X8

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      Conserved Domains (4) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:685 → 910
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:177 → 368
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:497 → 570
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    15. XM_006514983.5 → XP_006515046.1  phosphatidate phosphatase LPIN1 isoform X7

      See identical proteins and their annotated locations for XP_006515046.1

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A5F8MQ53
      Related
      ENSMUSP00000159076.2, ENSMUST00000239165.2
      Conserved Domains (4) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686 → 911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:177 → 369
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:498 → 571
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    16. XM_011243815.4 → XP_011242117.1  phosphatidate phosphatase LPIN1 isoform X14

      UniProtKB/TrEMBL
      Q8CFH3
      Conserved Domains (2) summary
      pfam08235
      Location:505 → 730
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:317 → 434
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    17. XM_006514984.5 → XP_006515047.1  phosphatidate phosphatase LPIN1 isoform X7

      See identical proteins and their annotated locations for XP_006515047.1

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A5F8MQ53
      Conserved Domains (4) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686 → 911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:177 → 369
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:498 → 571
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    18. XM_036157194.1 → XP_036013087.1  phosphatidate phosphatase LPIN1 isoform X14

      UniProtKB/TrEMBL
      Q8CFH3
      Conserved Domains (2) summary
      pfam08235
      Location:505 → 730
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:317 → 434
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    19. XM_030246560.2 → XP_030102420.1  phosphatidate phosphatase LPIN1 isoform X13

      UniProtKB/TrEMBL
      Q3U3C3, Q8CD95
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:653 → 878
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:465 → 538
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    20. XM_006514986.5 → XP_006515049.1  phosphatidate phosphatase LPIN1 isoform X7

      See identical proteins and their annotated locations for XP_006515049.1

      UniProtKB/Swiss-Prot
      Q91ZP3, Q9CQI2, Q9JLG6
      UniProtKB/TrEMBL
      A0A5F8MQ53
      Conserved Domains (4) summary
      pfam04571
      Location:1 → 106
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:686 → 911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam15402
      Location:177 → 369
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7
      pfam16876
      Location:498 → 571
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZP3.1 GenPept UniProtKB/Swiss-Prot:Q91ZP3

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