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    Dram1 DNA-damage regulated autophagy modulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 71712, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dram1provided by MGI
    Official Full Name
    DNA-damage regulated autophagy modulator 1provided by MGI
    Primary source
    MGI:MGI:1918962
    See related
    Ensembl:ENSMUSG00000020057 AllianceGenome:MGI:1918962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dram; 1200002N14Rik
    Summary
    Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; genitourinary system; gut; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in acute myocardial infarction. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 132.8), subcutaneous fat pad adult (RPKM 43.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dram1 in Genome Data Viewer
    Location:
    10 C1; 10 43.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88158663..88200218, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88322801..88364359, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 Neighboring gene predicted gene 8415 Neighboring gene WD repeat domain 75 pseudogene Neighboring gene predicted gene, 51779 Neighboring gene STARR-positive B cell enhancer ABC_E2332 Neighboring gene STARR-positive B cell enhancer ABC_E11453 Neighboring gene predicted gene, 40733 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits Neighboring gene STARR-positive B cell enhancer ABC_E5162 Neighboring gene STARR-positive B cell enhancer mm9_chr10:87872706-87873007 Neighboring gene STARR-positive B cell enhancer ABC_E2333 Neighboring gene STARR-positive B cell enhancer ABC_E3906

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages. Banducci-Karp A, et al. Cells, 2023 Mar 7. PMID 36980169, Free PMC Article
    2. DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. Yu M, et al. Int J Mol Sci, 2014 Oct 23. PMID 25342320, Free PMC Article
    3. Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice. Chen G, et al. Mol Med Rep, 2020 Sep. PMID 32582984, Free PMC Article
    4. DRAM-1 encodes multiple isoforms that regulate autophagy. Mah LY, et al. Autophagy, 2012 Jan. PMID 22082963, Free PMC Article
    5. mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Beaumatin F, et al. Mol Cell, 2019 Oct 3. PMID 31492633, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages.
      Title: DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages.
    2. Balance between autophagy and cell death is maintained by Polycomb-mediated regulation during stem cell differentiation.
      Title: Balance between autophagy and cell death is maintained by Polycomb-mediated regulation during stem cell differentiation.
    3. DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
      Title: DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
    4. DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
      Title: DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.
    5. Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.
      Title: Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice.
    6. DRAM-1 binds the membrane carrier protein SCAMP3 and the amino acid transporters SLC1A5 and LAT1, directing them to lysosomes and permitting efficient mTORC1 activation.
      Title: mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.
    7. DRAM1 knockdown aggravates OGD/R-induced cell injury.
      Title: DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
    8. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
      Title: DRAM-1 encodes multiple isoforms that regulate autophagy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA damage-regulated autophagy modulator protein 1
    Names
    damage-regulated autophagy modulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417838.1 → NP_001404767.1  DNA damage-regulated autophagy modulator protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125486

    2. NM_027878.3 → NP_082154.2  DNA damage-regulated autophagy modulator protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082154.2

      Status: VALIDATED

      Source sequence(s)
      AC125486
      Consensus CDS
      CCDS24109.1
      UniProtKB/Swiss-Prot
      Q78J26, Q9DC58
      Related
      ENSMUSP00000020249.2, ENSMUST00000020249.2
      Conserved Domains (1) summary
      pfam10277
      Location:7 → 224
      Frag1; Frag1/DRAM/Sfk1 family

    RNA

    1. NR_184639.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125486

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      88158663..88200218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243576.3 → XP_011241878.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241878.1

      Conserved Domains (1) summary
      pfam10277
      Location:1 → 166
      Frag1; Frag1/DRAM/Sfk1 family

    2. XM_017314100.2 → XP_017169589.1  DNA damage-regulated autophagy modulator protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:1 → 166
      Frag1; Frag1/DRAM/Sfk1 family

    RNA

    1. XR_004936281.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DC58.2 GenPept UniProtKB/Swiss-Prot:Q9DC58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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