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    Mybph myosin binding protein H [ Mus musculus (house mouse) ]

    Gene ID: 53311, updated on 27-Dec-2024

    Summary

    Official Symbol
    Mybphprovided by MGI
    Official Full Name
    myosin binding protein Hprovided by MGI
    Primary source
    MGI:MGI:1858196
    See related
    Ensembl:ENSMUSG00000042451 AllianceGenome:MGI:1858196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MyBP-H
    Summary
    Predicted to be involved in sarcomere organization. Predicted to be located in intracellular membraneless organelle and myosin filament. Predicted to be active in M band. Is expressed in diaphragm; heart; limb; musculature; and tail mesenchyme. Orthologous to human MYBPH (myosin binding protein H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 27.1), limb E14.5 (RPKM 24.7) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Mybph in Genome Data Viewer
    Location:
    1 E4; 1 58.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134121159..134128975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134193418..134201237)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46158 Neighboring gene STARR-seq mESC enhancer starr_02318 Neighboring gene chitinase 3 like 1 Neighboring gene STARR-positive B cell enhancer ABC_E1561 Neighboring gene adenosine A1 receptor Neighboring gene predicted gene, 32221 Neighboring gene STARR-seq mESC enhancer starr_02321 Neighboring gene predicted gene, 24517 Neighboring gene myogenin promoter-associated myogenic regulatory antisense lncRNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144854, MGC144855

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-binding protein H
    Names
    H-protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357515.1NP_001344444.1  myosin-binding protein H

      Status: VALIDATED

      Source sequence(s)
      AC137104
      Consensus CDS
      CCDS35713.1
      UniProtKB/Swiss-Prot
      E9QKH7, P70402
      UniProtKB/TrEMBL
      Q148P3
      Conserved Domains (3) summary
      cd00063
      Location:77163
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:388477
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197269
      Ig; Immunoglobulin domain
    2. NM_016749.2NP_058029.2  myosin-binding protein H

      See identical proteins and their annotated locations for NP_058029.2

      Status: VALIDATED

      Source sequence(s)
      AA673795, CB587371, U68267
      Consensus CDS
      CCDS35713.1
      UniProtKB/Swiss-Prot
      E9QKH7, P70402
      UniProtKB/TrEMBL
      Q148P3
      Related
      ENSMUSP00000042195.7, ENSMUST00000038445.13
      Conserved Domains (3) summary
      cd00063
      Location:77163
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:388477
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197269
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134121159..134128975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529753.4XP_006529816.1  myosin-binding protein H isoform X1

      UniProtKB/TrEMBL
      Q148P3
      Conserved Domains (3) summary
      cd00063
      Location:77163
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:388477
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:197269
      Ig; Immunoglobulin domain

    RNA

    1. XR_003956241.2 RNA Sequence

    2. XR_003956240.2 RNA Sequence