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    Foxg1 forkhead box G1 [ Mus musculus (house mouse) ]

    Gene ID: 15228, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Foxg1provided by MGI
    Official Full Name
    forkhead box G1provided by MGI
    Primary source
    MGI:MGI:1347464
    See related
    Ensembl:ENSMUSG00000020950 AllianceGenome:MGI:1347464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bf1; BF-1; Hfh9; Hfhbf1; 2900064B05Rik
    Summary
    Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuron differentiation; positive regulation of neuroblast proliferation; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; embryo ectoderm; gonad; and sensory organ. Used to study Rett syndrome. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 45.4), whole brain E14.5 (RPKM 34.5) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Foxg1 in Genome Data Viewer
    Location:
    12 B3; 12 21.78 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (49429666..49433650)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (49382883..49386867)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene predicted gene, 34304 Neighboring gene RIKEN cDNA 3110039M20 gene Neighboring gene predicted gene, 34381

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Foxg1 Upregulation Enhances Neocortical Activity. Tigani W, et al. Cereb Cortex, 2020 Jul 30. PMID 32383447
    2. FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice. Wang J, et al. Int J Mol Sci, 2022 Nov 29. PMID 36499306, Free PMC Article
    3. FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium. Ba R, et al. Sci Adv, 2023 Feb 15. PMID 36791184, Free PMC Article
    4. FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes. Miyoshi G, et al. Nat Commun, 2021 Jun 18. PMID 34145239, Free PMC Article
    5. A transgenic marker mouse line labels Cajal-Retzius cells from the cortical hem and thalamocortical axons. Zhao C, et al. Brain Res, 2006 Mar 10. PMID 16490185

    See all (584) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.
      Title: Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.
    2. Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1-Related Encephalopathy.
      Title: Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1-Related Encephalopathy.
    3. Foxg1 bimodally tunes L1-mRNA and -DNA dynamics in the developing murine neocortex.
      Title: Foxg1 bimodally tunes L1-mRNA and -DNA dynamics in the developing murine neocortex.
    4. Conditional Deletion of Foxg1 Delayed Myelination during Early Postnatal Brain Development.
      Title: Conditional Deletion of Foxg1 Delayed Myelination during Early Postnatal Brain Development.
    5. FOXG1 is involved in mouse ovarian functions and embryogenesis.
      Title: FOXG1 is involved in mouse ovarian functions and embryogenesis.
    6. FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium.
      Title: FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium.
    7. Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
      Title: Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1.
    8. FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.
      Title: FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice.
    9. Behavioral and brain anatomical analysis of Foxg1 heterozygous mice.
      Title: Behavioral and brain anatomical analysis of Foxg1 heterozygous mice.
    10. FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation.
      Title: FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation.
    Submit: New GeneRIF Correction See all GeneRIFs (61)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (8)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebral cortex development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron fate determination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pyramidal neuron migration to cerebral cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    forkhead box protein G1
    Names
    HNF-3/forkhead homolog, brain factor 1
    forkhead-related protein FKHL1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160112.1 → NP_001153584.1  forkhead box protein G1

      See identical proteins and their annotated locations for NP_001153584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the one-exon transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC162376, AK132305, AV226567, BC046958
      Consensus CDS
      CCDS25899.1
      UniProtKB/Swiss-Prot
      Q60987, Q80VP3
      UniProtKB/TrEMBL
      Q3V1Q8
      Related
      ENSMUSP00000136372.2, ENSMUST00000179669.3
      Conserved Domains (1) summary
      smart00339
      Location:173 → 261
      FH; FORKHEAD

    2. NM_008241.2 → NP_032267.1  forkhead box protein G1

      See identical proteins and their annotated locations for NP_032267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the 2-exon transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AV226567, BC046958, CA320871, U36760
      Consensus CDS
      CCDS25899.1
      UniProtKB/Swiss-Prot
      Q60987, Q80VP3
      UniProtKB/TrEMBL
      Q3V1Q8
      Related
      ENSMUSP00000021333.4, ENSMUST00000021333.5
      Conserved Domains (1) summary
      smart00339
      Location:173 → 261
      FH; FORKHEAD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      49429666..49433650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60987.1 GenPept UniProtKB/Swiss-Prot:Q60987

    Gene LinkOut

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