Gtf3c1 general transcription factor III C 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtf3c1provided by MGI
Official Full Name: general transcription factor III C 1provided by MGI
Primary source: MGI:MGI:107887
See related: Ensembl:ENSMUSG00000032777 AllianceGenome:MGI:107887
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Part of ribonucleoprotein complex. Is expressed in central nervous system; genitourinary system; and submandibular gland primordium. Orthologous to human GTF3C1 (general transcription factor IIIC subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 33.4), thymus adult (RPKM 24.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.01 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (125240126..125306860, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (125640954..125707688, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
Title: The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.
The partial purification of pol III transcription factors from PE and EC cells revealed that TFIIIC2 activity could be purified from both cell types, whereas TFIIIC1 activity was dramatically reduced in extracts from PE cells.
Title: The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125245 (e-PCR)
- UniSTS:162067

AU016385 (e-PCR)
- UniSTS:208207

PMC18813P1 (e-PCR)
- UniSTS:271734

Gtf3c1 (e-PCR), detects polymorphism
- UniSTS:143275

NoName (e-PCR)
- UniSTS:225263

07.MHAa43c7.seq (e-PCR)
- UniSTS:122874

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 5S class rRNA transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general transcription factor 3C polypeptide 1

Names: TF3C-alpha; TFIIIC 220 kDa subunit; TFIIIC box B-binding subunit; TFIIIC220; transcription factor IIIC 220 kDa subunit; transcription factor IIIC subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.