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    Chst4 carbohydrate sulfotransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 26887, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chst4provided by MGI
    Official Full Name
    carbohydrate sulfotransferase 4provided by MGI
    Primary source
    MGI:MGI:1349479
    See related
    Ensembl:ENSMUSG00000035930 AllianceGenome:MGI:1349479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GST-3; Gn6st-2; HEC-GlcNAc6ST
    Summary
    Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 33.9), large intestine adult (RPKM 14.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chst4 in Genome Data Viewer
    Location:
    8 D3; 8 57.38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110755776..110766033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110029075..110039401, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22664 Neighboring gene tyrosine aminotransferase Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene STARR-seq mESC enhancer starr_22666 Neighboring gene RIKEN cDNA 8030455M16 gene Neighboring gene zinc finger protein 612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-acetylglucosamine-6-O sulfation on intestinal mucins prevents obesity and intestinal inflammation by regulating gut microbiota. Abo H, et al. JCI Insight, 2023 Aug 22. PMID 37463055, Free PMC Article
    2. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Hemmerich S, et al. Immunity, 2001 Aug. PMID 11520459
    3. N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. Ito Z, et al. J Neurosci, 2010 Apr 28. PMID 20427653, Free PMC Article
    4. Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope. Bistrup A, et al. Am J Pathol, 2004 May. PMID 15111310, Free PMC Article
    5. Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing. Hiraoka N, et al. J Biol Chem, 2004 Jan 23. PMID 14593101

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GlcNAc6ST-2, whose expression is regulated by butyrate, is a major sulfotransferase in the biosynthesis of sulfomucins in the mouse colon, where they serve as a mucosal barrier against colonic inflammation
      Title: Sulfation of colonic mucins by N-acetylglucosamine 6-O-sulfotransferase-2 and its protective function in experimental colitis in mice.
    2. N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) deficiency results in elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X in high endothelial venules.
      Title: A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.
    3. plays a critical role in lymphocyte trafficking during chronic inflammation
      Title: Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing.
    4. GST-3 is responsible for MECA-79 defined luminal ligands
      Title: Detection of a sulfotransferase (HEC-GlcNAc6ST) in high endothelial venules of lymph nodes and in high endothelial venule-like vessels within ectopic lymphoid aggregates: relationship to the MECA-79 epitope.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylglucosamine 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein sulfation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 4
    Names
    L-selectin ligand sulfotransferase
    LSST
    N-acetylglucosamine 6-O-sulfotransferase 2
    carbohydrate (chondroitin 6/keratan) sulfotransferase 4
    galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
    glcNAc6ST-2
    high endothelial cell GlcNAC-6-sulphotransferase
    high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
    NP_001411745.1
    NP_001411746.1
    NP_036128.3
    XP_006531108.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424816.1 → NP_001411745.1  carbohydrate sulfotransferase 4

      Status: VALIDATED

      Source sequence(s)
      AC124409
      UniProtKB/TrEMBL
      A0A0R4J1C9

    2. NM_001424817.1 → NP_001411746.1  carbohydrate sulfotransferase 4

      Status: VALIDATED

      Source sequence(s)
      AC124409
      UniProtKB/TrEMBL
      A0A0R4J1C9

    3. NM_011998.5 → NP_036128.3  carbohydrate sulfotransferase 4

      See identical proteins and their annotated locations for NP_036128.3

      Status: VALIDATED

      Source sequence(s)
      AC124409
      Consensus CDS
      CCDS22659.1
      UniProtKB/Swiss-Prot
      Q9R1I1, Q9WUE5
      UniProtKB/TrEMBL
      A0A0R4J1C9
      Related
      ENSMUSP00000104845.3, ENSMUST00000109222.4
      Conserved Domains (1) summary
      cl21551
      Location:44 → 297
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110755776..110766033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531045.4 → XP_006531108.1  carbohydrate sulfotransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_006531108.1

      UniProtKB/Swiss-Prot
      Q9R1I1, Q9WUE5
      UniProtKB/TrEMBL
      A0A0R4J1C9
      Conserved Domains (1) summary
      cl21551
      Location:44 → 297
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1I1.1 GenPept UniProtKB/Swiss-Prot:Q9R1I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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