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    Eif4a2 eukaryotic translation initiation factor 4A2 [ Mus musculus (house mouse) ]

    Gene ID: 13682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4a2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A2provided by MGI
    Primary source
    MGI:MGI:106906
    See related
    Ensembl:ENSMUSG00000022884 AllianceGenome:MGI:106906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif4; Ddx2b; BM-010; eIF4A-II; eIF-4A-II; 4833432N07Rik
    Summary
    Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Is expressed in brain; early conceptus; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 124.6), bladder adult (RPKM 120.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif4a2 in Genome Data Viewer
    Location:
    16 B1; 16 13.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22924846..22932882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23107468..23114132)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40426 Neighboring gene kininogen 1 Neighboring gene STARR-seq mESC enhancer starr_40430 Neighboring gene STARR-seq mESC enhancer starr_40432 Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene predicted gene, 24201 Neighboring gene small nucleolar RNA, H/ACA box 81 Neighboring gene small nucleolar RNA, C/D box 2 Neighboring gene predicted gene, 26447 Neighboring gene predicted gene, 24616 Neighboring gene STARR-positive B cell enhancer ABC_E8623 Neighboring gene replication factor C (activator 1) 4 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23165651-23165889 Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene predicted pseudogene 6630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA world of the nucleolus: two major families of small RNAs defined by different box elements with related functions. Balakin AG, et al. Cell, 1996 Sep 6. PMID 8797828
    2. Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2. Sudo K, et al. Cytogenet Cell Genet, 1995. PMID 8521730
    3. Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status. Williams-Hill DM, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015395
    4. Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation. Galicia-Vázquez G, et al. PLoS One, 2014. PMID 24466343, Free PMC Article
    5. Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos. De Sousa PA, et al. Biol Reprod, 1998 Oct. PMID 9746750

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 4833432N07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of RNA-dependent RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic initiation factor 4A-II
    Names
    ATP-dependent RNA helicase eIF4A-2
    NP_001116509.1
    NP_001116510.1
    NP_001334108.1
    NP_038534.2
    XP_006521847.1
    XP_006521848.1
    XP_030104824.1
    XP_030104825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123037.2 → NP_001116509.1  eukaryotic initiation factor 4A-II isoform b

      See identical proteins and their annotated locations for NP_001116509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' coding region, which leads to a frameshift and use of an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS49806.1
      UniProtKB/TrEMBL
      E9Q561
      Related
      ENSMUSP00000127030.2, ENSMUST00000168891.8
      Conserved Domains (1) summary
      PTZ00424
      Location:18 → 312
      PTZ00424; helicase 45; Provisional

    2. NM_001123038.2 → NP_001116510.1  eukaryotic initiation factor 4A-II isoform c

      See identical proteins and their annotated locations for NP_001116510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3'-terminal exon, which leads to a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BG091741, BY286182, CF723811, CF898280, CK623185
      Consensus CDS
      CCDS49805.1
      UniProtKB/TrEMBL
      A0A338P6X5, Q8BTU6
      Related
      ENSMUSP00000090876.5, ENSMUST00000077605.12
      Conserved Domains (1) summary
      PTZ00424
      Location:21 → 360
      PTZ00424; helicase 45; Provisional

    3. NM_001347179.2 → NP_001334108.1  eukaryotic initiation factor 4A-II isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
      Source sequence(s)
      AC154540
      Consensus CDS
      CCDS84218.1
      UniProtKB/TrEMBL
      Q4FZL1
      Conserved Domains (1) summary
      PTZ00424
      Location:9 → 408
      PTZ00424; helicase 45; Provisional

    4. NM_013506.3 → NP_038534.2  eukaryotic initiation factor 4A-II isoform a

      See identical proteins and their annotated locations for NP_038534.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC154540, AK076509, BC094422, BY286182, CF723811
      Consensus CDS
      CCDS28074.1
      UniProtKB/Swiss-Prot
      P10630, Q61513, Q61514
      UniProtKB/TrEMBL
      Q4FZL1, Q52KC1
      Related
      ENSMUSP00000023599.7, ENSMUST00000023599.13
      Conserved Domains (1) summary
      PTZ00424
      Location:21 → 407
      PTZ00424; helicase 45; Provisional

    RNA

    1. NR_110335.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540, AK076509, AK132969, BC094422, BY286182, CF723811

    2. NR_152586.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154540

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22924846..22932882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521784.4 → XP_006521847.1  eukaryotic initiation factor 4A-II isoform X1

      See identical proteins and their annotated locations for XP_006521847.1

      UniProtKB/TrEMBL
      A0A338P6X5
      Related
      ENSMUSP00000156170.2, ENSMUST00000232287.2
      Conserved Domains (1) summary
      PTZ00424
      Location:9 → 361
      PTZ00424; helicase 45; Provisional

    2. XM_006521785.3 → XP_006521848.1  eukaryotic initiation factor 4A-II isoform X2

      See identical proteins and their annotated locations for XP_006521848.1

      UniProtKB/TrEMBL
      E9Q561
      Conserved Domains (1) summary
      PTZ00424
      Location:18 → 312
      PTZ00424; helicase 45; Provisional

    3. XM_030248964.1 → XP_030104824.1  eukaryotic initiation factor 4A-II isoform X3

      Conserved Domains (1) summary
      PTZ00424
      Location:18 → 265
      PTZ00424; helicase 45; Provisional

    4. XM_030248965.1 → XP_030104825.1  eukaryotic initiation factor 4A-II isoform X3

      Conserved Domains (1) summary
      PTZ00424
      Location:18 → 265
      PTZ00424; helicase 45; Provisional

    RNA

    1. XR_384524.4 RNA Sequence

    2. XR_384525.4 RNA Sequence

    3. XR_003951756.1 RNA Sequence

    4. XR_003951757.1 RNA Sequence

      Related
      ENSMUST00000147117.8

    5. XR_003951758.1 RNA Sequence

    6. XR_003951759.1 RNA Sequence

      Related
      ENSMUST00000131871.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10630.2 GenPept UniProtKB/Swiss-Prot:P10630

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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