Braf Braf transforming gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brafprovided by MGI
Official Full Name: Braf transforming geneprovided by MGI
Primary source: MGI:MGI:88190
See related: Ensembl:ENSMUSG00000002413 AllianceGenome:MGI:88190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik
Summary: Enables protein kinase activity. Involved in postsynaptic modulation of chemical synaptic transmission and protein phosphorylation. Acts upstream of or within several processes, including hemopoiesis; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma (multiple); papillary thyroid carcinoma; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 18.43 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (39580171..39702592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (39603231..39725658, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
Title: Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
Targeting miR-31 represses tumourigenesis and dedifferentiation of BRAF[V600E]-associated thyroid carcinoma.
Title: Targeting miR-31 represses tumourigenesis and dedifferentiation of BRAF(V600E)-associated thyroid carcinoma.
Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system.
Title: Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system.
HSPA8 Activates Wnt/beta-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation.
Title: HSPA8 Activates Wnt/β-Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA-Mediated CAV1 Degradation.
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.
Title: Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.
Telomere dysfunction in Tert knockout mice delays Braf[V600E] -induced melanoma development.
Title: Telomere dysfunction in Tert knockout mice delays Braf(V600E) -induced melanoma development.
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8[+] T cell infiltration in colorectal cancer.
Title: BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8(+) T cell infiltration in colorectal cancer.
STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
Title: STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
BRAF[V600E]-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.
Title: BRAF(V600E)-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism.
BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.
Title: BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes.

Submit: New GeneRIF Correction See all GeneRIFs (148)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (24) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI447469 (e-PCR)
- UniSTS:159496

C87398 (e-PCR)
- UniSTS:185664

AU015031 (e-PCR)
- UniSTS:167497

Braf (e-PCR), detects polymorphism
- UniSTS:141185

D6Mit153 (e-PCR), detects polymorphism
- UniSTS:130698

NoName (e-PCR)
- UniSTS:235419

NoName (e-PCR)
- UniSTS:235420

NoName (e-PCR)
- UniSTS:235421

NoName (e-PCR)
- UniSTS:235425

NoName (e-PCR)
- UniSTS:235427

Braf (e-PCR), detects polymorphism
- UniSTS:259512

RH137260 (e-PCR)
- UniSTS:219348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within head morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axon regeneration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stress fiber assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within thyroid gland development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase B-raf

Names: B-Raf proto-oncogene serine/threonine-protein kinase (p94); proto-oncogene B-Raf

NP_647455.3

EC 2.7.11.1

XP_006505416.1

EC 2.7.11.1

XP_006505418.1

EC 2.7.11.1

XP_006505421.1

EC 2.7.11.1

XP_011239436.1

EC 2.7.11.1

XP_011239437.1

EC 2.7.11.1

XP_011239438.2

EC 2.7.11.1

XP_011239439.2

EC 2.7.11.1

XP_011239440.1

EC 2.7.11.1

XP_011239441.1

EC 2.7.11.1

XP_030110954.1

EC 2.7.11.1

XP_030110955.1

EC 2.7.11.1

XP_036021639.1

EC 2.7.11.1

XP_036021640.1

EC 2.7.11.1

XP_036021641.1

EC 2.7.11.1

XP_036021642.1

EC 2.7.11.1

XP_036021643.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139294.5 → NP_647455.3 serine/threonine-protein kinase B-raf

See identical proteins and their annotated locations for NP_647455.3

Status: VALIDATED

Source sequence(s)

AC122345, AC163109, AK140431, BF466677, CK393545

Consensus CDS

CCDS39463.1

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Related

ENSMUSP00000002487.9, ENSMUST00000002487.15

Conserved Domains (4) summary

cd01816
Location:140 → 211

Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

cd14062
Location:500 → 752

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

pfam00069
Location:495 → 750

Pkinase; Protein kinase domain

pfam00130
Location:219 → 264

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

39580171..39702592 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165750.1 → XP_036021643.1 serine/threonine-protein kinase B-raf isoform X16

Conserved Domains (3) summary

cd14062
Location:558 → 804

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 326

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:324 → 383

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
XM_006505358.5 → XP_006505421.1 serine/threonine-protein kinase B-raf isoform X13

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Related

ENSMUSP00000099036.4, ENSMUST00000101497.4

Conserved Domains (3) summary

cd14062
Location:558 → 810

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 326

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:329 → 374

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_006505355.5 → XP_006505418.1 serine/threonine-protein kinase B-raf isoform X5

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:598 → 850

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 326

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:329 → 374

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036165747.1 → XP_036021640.1 serine/threonine-protein kinase B-raf isoform X10

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:570 → 822

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 326

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:324 → 383

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
XM_006505353.5 → XP_006505416.1 serine/threonine-protein kinase B-raf isoform X3

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:610 → 862

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 326

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:329 → 374

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011241139.4 → XP_011239441.1 serine/threonine-protein kinase B-raf isoform X12

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:561 → 813

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 329

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:332 → 377

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011241135.4 → XP_011239437.1 serine/threonine-protein kinase B-raf isoform X4

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:601 → 853

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 329

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:332 → 377

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011241138.4 → XP_011239440.1 serine/threonine-protein kinase B-raf isoform X8

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:573 → 825

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 329

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:332 → 377

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011241134.4 → XP_011239436.1 serine/threonine-protein kinase B-raf isoform X1

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:613 → 865

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 329

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:332 → 377

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036165746.1 → XP_036021639.1 serine/threonine-protein kinase B-raf isoform X2

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:613 → 865

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:248 → 329

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:327 → 386

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
XM_011241137.3 → XP_011239439.2 serine/threonine-protein kinase B-raf isoform X7

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:574 → 826

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:209 → 290

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:293 → 338

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_011241136.4 → XP_011239438.2 serine/threonine-protein kinase B-raf isoform X6

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:580 → 832

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:215 → 296

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:299 → 344

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_030255094.2 → XP_030110954.1 serine/threonine-protein kinase B-raf isoform X9

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:571 → 823

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:209 → 287

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:290 → 335

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036165748.1 → XP_036021641.1 serine/threonine-protein kinase B-raf isoform X14

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:463 → 715

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:138 → 219

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:217 → 276

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
XM_030255095.2 → XP_030110955.1 serine/threonine-protein kinase B-raf isoform X11

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:488 → 740

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:138 → 216

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

pfam00130
Location:219 → 264

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_036165749.1 → XP_036021642.1 serine/threonine-protein kinase B-raf isoform X15

UniProtKB/Swiss-Prot

E9QNG9, F6SZ47, P28028, Q3USE9

Conserved Domains (3) summary

cd14062
Location:448 → 700

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:138 → 216

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:214 → 273

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins