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    Fn3k fructosamine 3 kinase [ Mus musculus (house mouse) ]

    Gene ID: 63828, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fn3kprovided by MGI
    Official Full Name
    fructosamine 3 kinaseprovided by MGI
    Primary source
    MGI:MGI:1926834
    See related
    Ensembl:ENSMUSG00000025175 AllianceGenome:MGI:1926834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310074G21Rik
    Summary
    Enables protein-fructosamine 3-kinase activity. Involved in peptidyl-lysine deglycation. Acts upstream of or within fructosamine metabolic process. Is active in cytosol. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 11.4), liver E14 (RPKM 10.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fn3k in Genome Data Viewer
    Location:
    11 E2; 11 85.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121325779..121341316)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121434953..121450490)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Rab40B, member RAS oncogene family Neighboring gene microRNA 7236 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene fructosamine 3 kinase related protein Neighboring gene STARR-positive B cell enhancer mm9_chr11:121312999-121313300 Neighboring gene tubulin-specific chaperone d Neighboring gene STARR-seq mESC enhancer starr_31381 Neighboring gene zinc finger protein 750 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:121420970-121421165 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 Neighboring gene STARR-seq mESC enhancer starr_31382 Neighboring gene predicted gene, 53659

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes. Dunmore SJ, et al. Diabetes, 2018 Jan. PMID 29066600
    2. Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations. Pascal SM, et al. Am J Physiol Endocrinol Metab, 2010 Mar. PMID 20009024
    3. Increased protein glycation in fructosamine 3-kinase-deficient mice. Veiga da-Cunha M, et al. Biochem J, 2006 Oct 15. PMID 16819943, Free PMC Article
    4. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Sanghvi VR, et al. Cell, 2019 Aug 8. PMID 31398338, Free PMC Article
    5. Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. Delplanque J, et al. J Biol Chem, 2004 Nov 5. PMID 15331600

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FN3K is a targetable modulator of NRF2 activity in cancer.
      Title: The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
    2. Data conclude that FN3K may play a key role in the GGap and thus diabetes complications such that FN3K may be a potential predictor of the risk of diabetes complications. Pharmacological modifications of its activity may provide a novel approach to their prevention.
      Title: Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes.
    3. We conclude that, despite its ability to reduce the glycation of intracellular islet proteins, FN3K is neither required for the maintenance of beta-cell survival and function under control conditions.
      Title: Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations.
    4. These data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine.
      Title: Increased protein glycation in fructosamine 3-kinase-deficient mice.
    5. fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate
      Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-fructosamine 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-fructosamine 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-fructosamine 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-ribulosamine 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fructosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine deglycation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deglycation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deglycation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructosamine-3-kinase
    Names
    protein-psicosamine 3-kinase FN3K
    protein-ribulosamine 3-kinase FN3K
    NP_001033788.1
    NP_071297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038699.2 → NP_001033788.1  fructosamine-3-kinase isoform b

      See identical proteins and their annotated locations for NP_001033788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site and segment for its 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus when it is compared to isoform a.
      Source sequence(s)
      BC054374, BY142714
      Consensus CDS
      CCDS25777.1
      UniProtKB/TrEMBL
      Q7TQJ3
      Related
      ENSMUSP00000099303.4, ENSMUST00000103014.4
      Conserved Domains (1) summary
      cl21453
      Location:3 → 157
      PKc_like; Protein Kinases, catalytic domain

    2. NM_022014.4 → NP_071297.1  fructosamine-3-kinase isoform a

      See identical proteins and their annotated locations for NP_071297.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AA058133, AI464555, BU571242, BY142714
      Consensus CDS
      CCDS25776.1
      UniProtKB/Swiss-Prot
      Q9D6N6, Q9ER35
      Related
      ENSMUSP00000026175.3, ENSMUST00000026175.9
      Conserved Domains (1) summary
      cl21453
      Location:3 → 309
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121325779..121341316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER35.1 GenPept UniProtKB/Swiss-Prot:Q9ER35

    Gene LinkOut

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