Micu3 mitochondrial calcium uptake family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Micu3provided by MGI
Official Full Name: mitochondrial calcium uptake family, member 3provided by MGI
Primary source: MGI:MGI:1925756
See related: Ensembl:ENSMUSG00000039478 AllianceGenome:MGI:1925756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Efha2; 2900075B16Rik
Summary: Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion. Is active in mitochondrion. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (40760394..40841824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40307438..40388782)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
Title: MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
Title: Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca(2+) uptake. Silencing of MICU3 in primary cortical neurons impairs Ca(2+) signals elicited by synaptic activity, thus suggesting a specific role in regulating neuronal function.
Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488970

BB211804 (e-PCR)
- UniSTS:185754

NoName (e-PCR)
- UniSTS:495813

D8Mit339 (e-PCR), detects polymorphism
- UniSTS:131552

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion sensor activity	ISO Inferred from Sequence Orthology more info
enables calcium ion sensor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect positive regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcium uptake protein 3, mitochondrial

Names: EF-hand domain family, member A2; EF-hand domain-containing family member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030110.2 → NP_084386.1 calcium uptake protein 3, mitochondrial

See identical proteins and their annotated locations for NP_084386.1

Status: VALIDATED

Source sequence(s)

AC102680, AC160537

Consensus CDS

CCDS52545.1

UniProtKB/Swiss-Prot

Q9CTY5

Related

ENSMUSP00000070241.8, ENSMUST00000068999.14

Conserved Domains (2) summary

pfam05763
Location:349 → 437

DUF835; Protein of unknown function (DUF835)

pfam13833
Location:442 → 495

EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

40760394..40841824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509522.4 → XP_006509585.1 calcium uptake protein 3, mitochondrial isoform X1

Conserved Domains (2) summary

PTZ00183
Location:231 → 346

PTZ00183; centrin; Provisional

cd16175
Location:229 → 483

EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins
XM_017313013.3 → XP_017168502.1 calcium uptake protein 3, mitochondrial isoform X2

UniProtKB/TrEMBL

A0JLX6

Conserved Domains (1) summary

cd16175
Location:60 → 327

EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins