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    Zfp827 zinc finger protein 827 [ Mus musculus (house mouse) ]

    Gene ID: 622675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp827provided by MGI
    Official Full Name
    zinc finger protein 827provided by MGI
    Primary source
    MGI:MGI:2444807
    See related
    Ensembl:ENSMUSG00000071064 AllianceGenome:MGI:2444807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf827; 2810449M09Rik; D630040G17Rik
    Summary
    Predicted to enable NuRD complex binding activity. Predicted to be involved in several processes, including establishment of protein localization to telomere; negative regulation of shelterin complex assembly; and regulation of DNA-templated transcription. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human ZNF827 (zinc finger protein 827). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.9), whole brain E14.5 (RPKM 3.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp827 in Genome Data Viewer
    Location:
    8 C1; 8 37.36 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79753754..79920397)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (79027486..79193768)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22004 Neighboring gene predicted gene, 39204 Neighboring gene STARR-positive B cell enhancer ABC_E8250 Neighboring gene predicted gene, 22044 Neighboring gene predicted gene, 30271 Neighboring gene RIKEN cDNA 1700011L22 gene Neighboring gene predicted gene, 30329 Neighboring gene methylmalonic aciduria (cobalamin deficiency) type A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NuRD complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NuRD complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization to telomere ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of shelterin complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of shelterin complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 827

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294279.2 → NP_001281208.1  zinc finger protein 827 isoform 2

      See identical proteins and their annotated locations for NP_001281208.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC101790, AC123597
      Consensus CDS
      CCDS80900.1
      UniProtKB/TrEMBL
      G5E8U2
      Related
      ENSMUSP00000113199.2, ENSMUST00000119254.8
      Conserved Domains (4) summary
      COG5048
      Location:351 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain

    2. NM_178267.4 → NP_839998.2  zinc finger protein 827 isoform 1

      See identical proteins and their annotated locations for NP_839998.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC101790, AC123597
      Consensus CDS
      CCDS52604.1
      UniProtKB/Swiss-Prot
      B2RXD8, Q505G8, Q5M7B0
      Related
      ENSMUSP00000096214.3, ENSMUST00000098614.9
      Conserved Domains (4) summary
      COG5048
      Location:351 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:385 → 410
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      79753754..79920397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531246.3 → XP_006531309.1  zinc finger protein 827 isoform X5

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:351 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1153 → 1177
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1138 → 1162
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_030243704.2 → XP_030099564.1  zinc finger protein 827 isoform X6

      UniProtKB/TrEMBL
      A0A571BE87
      Related
      ENSMUSP00000158613.2, ENSMUST00000238669.2
      Conserved Domains (5) summary
      COG5048
      Location:351 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:816 → 836
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1147 → 1171
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1132 → 1156
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. XM_036154209.1 → XP_036010102.1  zinc finger protein 827 isoform X7

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:344 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:366 → 386
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:809 → 829
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1146 → 1170
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1131 → 1155
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_036154222.1 → XP_036010115.1  zinc finger protein 827 isoform X13

      Conserved Domains (3) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:433 → 458
      zf-H2C2_2; Zinc-finger double domain

    5. XM_036154223.1 → XP_036010116.1  zinc finger protein 827 isoform X14

      Conserved Domains (2) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036154212.1 → XP_036010105.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    7. XM_036154215.1 → XP_036010108.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    8. XM_036154213.1 → XP_036010106.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    9. XM_036154211.1 → XP_036010104.1  zinc finger protein 827 isoform X9

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    10. XM_036154221.1 → XP_036010114.1  zinc finger protein 827 isoform X12

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    11. XM_036154219.1 → XP_036010112.1  zinc finger protein 827 isoform X12

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    12. XM_036154220.1 → XP_036010113.1  zinc finger protein 827 isoform X12

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    13. XM_036154218.1 → XP_036010111.1  zinc finger protein 827 isoform X11

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    14. XM_036154216.1 → XP_036010109.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    15. XM_036154214.1 → XP_036010107.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    16. XM_036154217.1 → XP_036010110.1  zinc finger protein 827 isoform X10

      Conserved Domains (4) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:862 → 884
      zf-C2H2; Zinc finger, C2H2 type

    17. XM_006531242.5 → XP_006531305.1  zinc finger protein 827 isoform X1

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1201 → 1225
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1186 → 1210
      zf-H2C2_5; C2H2-type zinc-finger domain

    18. XM_036154206.1 → XP_036010099.1  zinc finger protein 827 isoform X2

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1197 → 1221
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1182 → 1206
      zf-H2C2_5; C2H2-type zinc-finger domain

    19. XM_036154207.1 → XP_036010100.1  zinc finger protein 827 isoform X3

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1195 → 1219
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1180 → 1204
      zf-H2C2_5; C2H2-type zinc-finger domain

    20. XM_036154208.1 → XP_036010101.1  zinc finger protein 827 isoform X4

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:864 → 884
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1191 → 1215
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1176 → 1200
      zf-H2C2_5; C2H2-type zinc-finger domain

    21. XM_036154210.1 → XP_036010103.1  zinc finger protein 827 isoform X8

      UniProtKB/TrEMBL
      A0A571BE87
      Conserved Domains (5) summary
      COG5048
      Location:399 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:786 → 806
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:1123 → 1147
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:1108 → 1132
      zf-H2C2_5; C2H2-type zinc-finger domain

    RNA

    1. XR_004934863.1 RNA Sequence

    2. XR_004934865.1 RNA Sequence

    3. XR_004934864.1 RNA Sequence

    4. XR_004934866.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505G8.2 GenPept UniProtKB/Swiss-Prot:Q505G8

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