Nfic nuclear factor I/C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nficprovided by MGI
Official Full Name: nuclear factor I/Cprovided by MGI
Primary source: MGI:MGI:109591
See related: Ensembl:ENSMUSG00000055053 AllianceGenome:MGI:109591
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NF1-C; 1110019L22Rik; 1500041O16Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within odontogenesis of dentin-containing tooth. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and skeletal musculature. Orthologous to human NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 27.2), lung adult (RPKM 13.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81232025..81267753, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81396191..81431919, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
Title: NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
Title: NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
Title: Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
Title: Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
Title: NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
the Runx2-Nfic-Osx pathway is one of the key factors that regulate ameloblast differentiation.
Title: The Nfic-osterix pathway regulates ameloblast differentiation and enamel formation.
An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation.
Title: An Nfic-hedgehog signaling cascade regulates tooth root development.
NFI-C acts as a regulator of the phased hepatocyte proliferation during liver regeneration.
Title: Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.
Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs.
Title: NFI-C regulates osteoblast differentiation via control of osterix expression.
The purpose of this study was to identify the molecular interactions between NFI-C and TGF-beta1 signaling in mouse odontoblasts.
Title: Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI746521 (e-PCR)
- UniSTS:165714

AW822021 (e-PCR)
- UniSTS:208580

RH124965 (e-PCR)
- UniSTS:161787

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor 1 C-type

Names: CCAAT-box-binding transcription factor; CTF; NF-I/C; NFI-C; TGGCA-binding protein; nuclear factor 1-C2; nuclear factor 1/C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008688.3 → NP_032714.1 nuclear factor 1 C-type isoform a

See identical proteins and their annotated locations for NP_032714.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes a longer isoform (a).

Source sequence(s)

AC155937, AK087539, BY226699

Consensus CDS

CCDS24058.1

UniProtKB/Swiss-Prot

O09072, P70255, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3

UniProtKB/TrEMBL

A0A1Y7VK55

Related

ENSMUSP00000020461.9, ENSMUST00000020461.15

Conserved Domains (3) summary

pfam00859
Location:217 → 424

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:68 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_026756.2 → NP_081032.2 nuclear factor 1 C-type isoform b

See identical proteins and their annotated locations for NP_081032.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate penultimate exon, resulting in a novel 3' coding region and shorter 3' UTR, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.

Source sequence(s)

AC155937, AK147496, BY226699

Consensus CDS

CCDS35999.1

UniProtKB/TrEMBL

A0A1Y7VK55, Q3UHA6

Related

ENSMUSP00000100958.4, ENSMUST00000105321.10

Conserved Domains (3) summary

pfam00859
Location:217 → 423

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:68 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

81232025..81267753 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244940.1 → XP_030100800.1 nuclear factor 1 C-type isoform X2

UniProtKB/TrEMBL

A0A1Y7VK55

Conserved Domains (3) summary

pfam00859
Location:208 → 414

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 164

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006513335.4 → XP_006513398.1 nuclear factor 1 C-type isoform X1

See identical proteins and their annotated locations for XP_006513398.1

UniProtKB/TrEMBL

A0A1Y7VK55

Related

ENSMUSP00000113046.2, ENSMUST00000117966.2

Conserved Domains (3) summary

pfam00859
Location:208 → 415

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 164

MH1; N-terminal Mad Homology 1 (MH1) domain