Disp1 dispatched RND transporter family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Disp1provided by MGI
Official Full Name: dispatched RND transporter family member 1provided by MGI
Primary source: MGI:MGI:1916147
See related: Ensembl:ENSMUSG00000030768 AllianceGenome:MGI:1916147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DispA; 1190008H24Rik
Summary: Acts upstream of or within several processes, including embryonic pattern specification; patched ligand maturation; and regionalization. Predicted to be active in membrane. Is expressed in several structures, including embryo ectoderm; foot bone; notochord; palatal shelf; and urinary system. Orthologous to human DISP1 (dispatched RND transporter family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 8.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (182867828..183010257, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (183086264..183221537, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog.
Title: Dispatched uses Na(+) flux to power release of lipid-modified Hedgehog.
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Title: Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells.
Title: Cleavage activates dispatched for Sonic Hedgehog ligand release.
Disp1 regulates growth of mammalian long bones through the control of Indian hedgehog distribution.
Title: Disp1 regulates growth of mammalian long bones through the control of Ihh distribution.
Disp1 has a role in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand
Title: Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand.
Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh.
Title: Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
Disp is required for the movement of Hh protein from its sites of synthesis in mice
Title: Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

D1Mit406 (e-PCR), detects polymorphism
- UniSTS:128768

NoName (e-PCR)
- UniSTS:234287

RH135020 (e-PCR)
- UniSTS:218297

Z7134 (e-PCR), detects polymorphism
- UniSTS:255201

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular carrier activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diaphragm development	IEA Inferred from Electronic Annotation more info
involved_in diaphragm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within patched ligand maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within patched ligand maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptide transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein dispatched homolog 1

Names: dispatched A; dispatched homolog 1; mdispa; twelve-pass transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278218.1 → NP_001265147.1 protein dispatched homolog 1

See identical proteins and their annotated locations for NP_001265147.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AC122792, BB732349, BC043102

Consensus CDS

CCDS56661.1

UniProtKB/Swiss-Prot

Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62

Related

ENSMUSP00000141747.2, ENSMUST00000195372.2

Conserved Domains (1) summary

cl25655
Location:434 → 1114

Patched; Patched family
NM_001278219.1 → NP_001265148.1 protein dispatched homolog 1

See identical proteins and their annotated locations for NP_001265148.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AC122792, AK138276, BB732349, BC043102

Consensus CDS

CCDS56661.1

UniProtKB/Swiss-Prot

Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62

Conserved Domains (1) summary

cl25655
Location:434 → 1114

Patched; Patched family
NM_001278220.1 → NP_001265149.1 protein dispatched homolog 1

See identical proteins and their annotated locations for NP_001265149.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AC122792, AY144589, BB732349, BC043102, BY792654

Consensus CDS

CCDS56661.1

UniProtKB/Swiss-Prot

Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62

Related

ENSMUSP00000126742.2, ENSMUST00000171366.7

Conserved Domains (1) summary

cl25655
Location:434 → 1114

Patched; Patched family
NM_026866.3 → NP_081142.3 protein dispatched homolog 1

See identical proteins and their annotated locations for NP_081142.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.

Source sequence(s)

AC122792, AK138276, BB732349, BC043102

Consensus CDS

CCDS56661.1

UniProtKB/Swiss-Prot

Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62

Related

ENSMUSP00000003035.6, ENSMUST00000003035.12

Conserved Domains (1) summary

cl25655
Location:434 → 1114

Patched; Patched family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

182867828..183010257 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153394.1 → XP_036009287.1 protein dispatched homolog 1 isoform X3

UniProtKB/Swiss-Prot

Q3TDN0, Q3UUL8, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62

Conserved Domains (1) summary

cl25655
Location:434 → 1114

Patched; Patched family
XM_006535596.5 → XP_006535659.1 protein dispatched homolog 1 isoform X2

Conserved Domains (1) summary

cl25655
Location:468 → 1148

Patched; Patched family
XM_036153395.1 → XP_036009288.1 protein dispatched homolog 1 isoform X4

Conserved Domains (1) summary

cl25655
Location:241 → 921

Patched; Patched family
XM_036153391.1 → XP_036009284.1 protein dispatched homolog 1 isoform X1

Conserved Domains (1) summary

cl25655
Location:470 → 1150

Patched; Patched family