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    Tmem170b transmembrane protein 170B [ Mus musculus (house mouse) ]

    Gene ID: 621976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem170bprovided by MGI
    Official Full Name
    transmembrane protein 170Bprovided by MGI
    Primary source
    MGI:MGI:3647046
    See related
    Ensembl:ENSMUSG00000087370 AllianceGenome:MGI:3647046
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG621976
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human TMEM170B (transmembrane protein 170B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 6.2), CNS E18 (RPKM 5.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem170b in Genome Data Viewer
    Location:
    13 A4; 13 20.55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41759358..41794830)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41605882..41641354)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 9 Neighboring gene predicted gene, 32448 Neighboring gene STARR-seq mESC enhancer starr_34303 Neighboring gene STARR-positive B cell enhancer ABC_E2404 Neighboring gene predicted gene, 32401 Neighboring gene predicted gene, 32184 Neighboring gene STARR-positive B cell enhancer ABC_E7229 Neighboring gene STARR-positive B cell enhancer ABC_E5388 Neighboring gene STARR-seq mESC enhancer starr_34304 Neighboring gene STARR-positive B cell enhancer ABC_E4066 Neighboring gene STARR-positive B cell enhancer mm9_chr13:41733437-41733738 Neighboring gene VISTA enhancer mm192 Neighboring gene predicted gene 5082 Neighboring gene predicted gene, 40925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 170B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163572.2 → NP_001157044.1  transmembrane protein 170B isoform 1

      See identical proteins and their annotated locations for NP_001157044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC133159, AC154848
      Consensus CDS
      CCDS49248.1
      UniProtKB/Swiss-Prot
      P86050
      Related
      ENSMUSP00000131144.2, ENSMUST00000129449.3
      Conserved Domains (1) summary
      pfam10190
      Location:28 → 132
      Tmemb_170; Putative transmembrane protein 170

    2. NM_001368686.1 → NP_001355615.1  transmembrane protein 170B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133159, AC154848
      Consensus CDS
      CCDS88445.1
      UniProtKB/TrEMBL
      A0A1Y7VMZ7
      Related
      ENSMUSP00000152170.2, ENSMUST00000221694.2
      Conserved Domains (1) summary
      pfam10190
      Location:31 → 75
      Tmemb_170; Putative transmembrane protein 170

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      41759358..41794830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P86050.1 GenPept UniProtKB/Swiss-Prot:P86050

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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