U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Rcor3 REST corepressor 3 [ Mus musculus (house mouse) ]

    Gene ID: 214742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rcor3provided by MGI
    Official Full Name
    REST corepressor 3provided by MGI
    Primary source
    MGI:MGI:2441920
    See related
    Ensembl:ENSMUSG00000037395 AllianceGenome:MGI:2441920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921514E24Rik; C730034D20Rik; E130101E15Rik
    Summary
    Enables enzyme binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; limb; and liver. Orthologous to human RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.4), ovary adult (RPKM 4.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rcor3 in Genome Data Viewer
    Location:
    1 H6; 1 97.23 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191782842..191822371, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (192098546..192138074, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene microRNA 3473c Neighboring gene TNF receptor-associated factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E11114 Neighboring gene STARR-positive B cell enhancer ABC_E11115 Neighboring gene glutathione S-transferase, pi, pseudogene Neighboring gene predicted gene 10516 Neighboring gene predicted gene, 39745 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 1 Neighboring gene STARR-seq mESC enhancer starr_03453 Neighboring gene STARR-seq mESC enhancer starr_03454 Neighboring gene STARR-seq mESC enhancer starr_03455 Neighboring gene STARR-seq mESC enhancer starr_03457 Neighboring gene STARR-seq mESC enhancer starr_03458

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC28186

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding PubMed 
    enables protein binding PubMed 
    enables transcription corepressor activity  
    Component Evidence Code Pubs
    located_in cytosol  
    part_of histone deacetylase complex  
    located_in nucleoplasm  
    located_in nucleus  
    part_of transcription regulator complex  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290278.2NP_001277207.1  REST corepressor 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Consensus CDS
      CCDS69996.1
      UniProtKB/Swiss-Prot
      Q6PGA0
      Related
      ENSMUSP00000106473.4, ENSMUST00000110849.10
      Conserved Domains (3) summary
      smart00717
      Location:143189
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:57108
      ELM2; ELM2 domain
      cl21498
      Location:144188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. NM_001290279.2NP_001277208.1  REST corepressor 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Consensus CDS
      CCDS78777.1
      UniProtKB/TrEMBL
      A0A0A6YWY4
      Related
      ENSMUSP00000141753.2, ENSMUST00000192491.6
      Conserved Domains (2) summary
      pfam01448
      Location:57108
      ELM2; ELM2 domain
      cl21498
      Location:144188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. NM_001290280.2NP_001277209.1  REST corepressor 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Consensus CDS
      CCDS78778.1
      UniProtKB/TrEMBL
      A0A0A6YWP7
      Related
      ENSMUSP00000141637.2, ENSMUST00000192128.6
      Conserved Domains (4) summary
      smart00717
      Location:345390
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:345388
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:57108
      ELM2; ELM2 domain
      cl21498
      Location:144188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    4. NM_001290282.2NP_001277211.1  REST corepressor 3 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      UniProtKB/TrEMBL
      B2RSN6
      Conserved Domains (2) summary
      smart00717
      Location:2470
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cl21498
      Location:2569
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    5. NM_001346740.2NP_001333669.1  REST corepressor 3 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Consensus CDS
      CCDS83667.1
      UniProtKB/TrEMBL
      A0A0A6YXM5
      Related
      ENSMUSP00000142054.2, ENSMUST00000192866.6
    6. NM_001403274.1NP_001390203.1  REST corepressor 3 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
    7. NM_001403275.1NP_001390204.1  REST corepressor 3 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC182250, LO018690
    8. NM_144814.4NP_659063.3  REST corepressor 3 isoform a

      See identical proteins and their annotated locations for NP_659063.3

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Consensus CDS
      CCDS69995.1
      UniProtKB/Swiss-Prot
      Q6PGA0
      UniProtKB/TrEMBL
      B2RSN6
      Related
      ENSMUSP00000073004.8, ENSMUST00000073279.13
      Conserved Domains (3) summary
      smart00717
      Location:143189
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:57108
      ELM2; ELM2 domain
      cl21498
      Location:144188
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RNA

    1. NR_175372.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC175315, AC182250, LO018690
      Related
      ENSMUST00000192158.6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      191782842..191822371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252872.2XP_030108732.2  REST corepressor 3 isoform X2

      Conserved Domains (2) summary
      pfam01448
      Location:139190
      ELM2; ELM2 domain
      cl21498
      Location:226270
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. XM_030252875.2XP_030108735.2  REST corepressor 3 isoform X3

      Conserved Domains (2) summary
      pfam01448
      Location:139190
      ELM2; ELM2 domain
      cl21498
      Location:226270
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. XM_006497244.4XP_006497307.1  REST corepressor 3 isoform X4

      See identical proteins and their annotated locations for XP_006497307.1

      Conserved Domains (3) summary
      pfam00249
      Location:226269
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09770
      Location:269420
      PAT1; Topoisomerase II-associated protein PAT1
      cl21498
      Location:2569
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    4. XM_011238931.3XP_011237233.1  REST corepressor 3 isoform X4

      See identical proteins and their annotated locations for XP_011237233.1

      Conserved Domains (3) summary
      pfam00249
      Location:226269
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09770
      Location:269420
      PAT1; Topoisomerase II-associated protein PAT1
      cl21498
      Location:2569
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    5. XM_030252885.2XP_030108745.2  REST corepressor 3 isoform X5

      Conserved Domains (2) summary
      pfam01448
      Location:139190
      ELM2; ELM2 domain
      cl21498
      Location:226270
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RNA

    1. XR_001783754.2 RNA Sequence

    2. XR_003954421.2 RNA Sequence

    3. XR_003954423.2 RNA Sequence

    4. XR_003954422.2 RNA Sequence

    5. XR_003954420.2 RNA Sequence

    6. XR_003954419.2 RNA Sequence

    Loading
    Loading
    External link. Please review our privacy policy.