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    Dnlz DNL-type zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 52838, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnlzprovided by MGI
    Official Full Name
    DNL-type zinc fingerprovided by MGI
    Primary source
    MGI:MGI:106559
    See related
    Ensembl:ENSMUSG00000075467 AllianceGenome:MGI:106559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HEP1; D2Bwg1335e; 1110034G11Rik
    Summary
    Predicted to enable protein folding chaperone and protein-folding chaperone binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; protein import into mitochondrial matrix; and protein stabilization. Located in mitochondrion. Orthologous to human DNLZ (DNL-type zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 15.1), CNS E11.5 (RPKM 13.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnlz in Genome Data Viewer
    Location:
    2 A3; 2 18.87 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26238130..26242122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26348118..26352110, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 187 Neighboring gene predicted gene, 35807 Neighboring gene STARR-seq mESC enhancer starr_03980 Neighboring gene predicted gene, 52505 Neighboring gene G-protein signalling modulator 1 (AGS3-like, C. elegans) Neighboring gene predicted gene 13562 Neighboring gene caspase recruitment domain family, member 9 Neighboring gene small nuclear RNA activating complex, polypeptide 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    2. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNL-type zinc finger protein
    Names
    hsp70-escort protein 1
    mtHsp70-escort protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139503.1 → NP_001132975.1  DNL-type zinc finger protein isoform 2

      See identical proteins and their annotated locations for NP_001132975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) skips an exon in the coding region, compared to variant (1). The encoded protein (isoform 2) has a shorter and distinct C-terminus that lacks a zinc finger DNL domain, compared to isoform 1.
      Source sequence(s)
      AK142070, BC031595
      UniProtKB/TrEMBL
      Q8K0F4
      Related
      ENSMUST00000125848.2

    2. NM_001139504.1 → NP_001132976.1  DNL-type zinc finger protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a frame-shifting alternate splice site in the coding region, compared to variant (1). The encoded protein (isoform 3) has a shorter and distinct C-terminus that lacks a zinc finger DNL domain, compared to isoform 1.
      Source sequence(s)
      AK142070, BC031595, BY266852
      UniProtKB/Swiss-Prot
      Q9D113
      UniProtKB/TrEMBL
      Q8K0F4

    3. NM_026828.3 → NP_081104.1  DNL-type zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_081104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK142070, BC031595
      Consensus CDS
      CCDS38083.1
      UniProtKB/Swiss-Prot
      B2RTG5, Q9D113
      Related
      ENSMUSP00000028295.9, ENSMUST00000028295.9
      Conserved Domains (1) summary
      pfam05180
      Location:74 → 139
      zf-DNL; DNL zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26238130..26242122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D113.1 GenPept UniProtKB/Swiss-Prot:Q9D113

    Gene LinkOut

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