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    Stx18 syntaxin 18 [ Mus musculus (house mouse) ]

    Gene ID: 71116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stx18provided by MGI
    Official Full Name
    syntaxin 18provided by MGI
    Primary source
    MGI:MGI:1918366
    See related
    Ensembl:ENSMUSG00000029125 AllianceGenome:MGI:1918366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810035L21Rik; 4933425D03Rik
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of ER to Golgi vesicle-mediated transport; regulation of organelle organization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 18.0), CNS E18 (RPKM 17.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stx18 in Genome Data Viewer
    Location:
    5 B3; 5 20.21 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38194073..38295114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38036729..38137770)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12911 Neighboring gene STARR-seq mESC enhancer starr_12912 Neighboring gene predicted gene, 54328 Neighboring gene VISTA enhancer mm429 Neighboring gene predicted gene, 40289 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38414144-38414444 Neighboring gene VISTA enhancer mm1165 Neighboring gene neuron specific gene family member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:38602912-38603212 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene Ly1 antibody reactive clone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. Hatsuzawa K, et al. Mol Biol Cell, 2006 Sep. PMID 16790498, Free PMC Article
    2. Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18. Laniosz V, et al. J Virol, 2007 Jul. PMID 17475643, Free PMC Article
    3. Sec22b is a negative regulator of phagocytosis in macrophages. Hatsuzawa K, et al. Mol Biol Cell, 2009 Oct. PMID 19710423, Free PMC Article
    4. Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Hurle B, et al. Genomics, 2001 Oct. PMID 11597144
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ER to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of organelle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of organelle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289535.1 → NP_001276464.1  syntaxin-18 isoform 2

      See identical proteins and their annotated locations for NP_001276464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC115931, AK007700, AK169273, BY037320
      Consensus CDS
      CCDS71583.1
      UniProtKB/Swiss-Prot
      Q8VDS8
      Related
      ENSMUSP00000031008.7, ENSMUST00000031008.13
      Conserved Domains (2) summary
      cd15850
      Location:245 → 303
      SNARE_syntaxin18; SNARE motif, subgroup Qa
      pfam10496
      Location:4 → 96
      Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

    2. NM_001289536.1 → NP_001276465.1  syntaxin-18 isoform 3

      See identical proteins and their annotated locations for NP_001276465.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC115931, AC121811
      Consensus CDS
      CCDS80270.1
      UniProtKB/Swiss-Prot
      Q8VDS8
      Related
      ENSMUSP00000038205.9, ENSMUST00000042146.15
      Conserved Domains (2) summary
      cd15850
      Location:219 → 277
      SNARE_syntaxin18; SNARE motif, subgroup Qa
      pfam10496
      Location:4 → 96
      Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

    3. NM_001359398.1 → NP_001346327.1  syntaxin-18 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC115931, AC121811
      UniProtKB/TrEMBL
      D3YY98
      Related
      ENSMUSP00000118218.2, ENSMUST00000154929.5
      Conserved Domains (1) summary
      cd15850
      Location:191 → 249
      SNARE_syntaxin18; SNARE motif, subgroup Qa

    4. NM_026959.3 → NP_081235.2  syntaxin-18 isoform 1

      See identical proteins and their annotated locations for NP_081235.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC115931, AK169273, BY037320
      Consensus CDS
      CCDS19250.1
      UniProtKB/Swiss-Prot
      Q3TDJ0, Q8VDS8, Q9D8T6
      Related
      ENSMUSP00000109761.3, ENSMUST00000114126.9
      Conserved Domains (2) summary
      cd15850
      Location:245 → 303
      SNARE_syntaxin18; SNARE motif, subgroup Qa
      pfam10496
      Location:4 → 96
      Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      38194073..38295114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254807.1 → XP_030110667.1  syntaxin-18 isoform X1

      UniProtKB/TrEMBL
      D3YY98
      Conserved Domains (1) summary
      cd15850
      Location:191 → 249
      SNARE_syntaxin18; SNARE motif, subgroup Qa

    2. XM_006504112.5 → XP_006504175.1  syntaxin-18 isoform X2

      UniProtKB/TrEMBL
      D3YY98
      Conserved Domains (1) summary
      cd15850
      Location:164 → 222
      SNARE_syntaxin18; SNARE motif, subgroup Qa
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDS8.2 GenPept UniProtKB/Swiss-Prot:Q8VDS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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