Nqo1 NAD(P)H dehydrogenase, quinone 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nqo1provided by MGI
Official Full Name: NAD(P)H dehydrogenase, quinone 1provided by MGI
Primary source: MGI:MGI:103187
See related: Ensembl:ENSMUSG00000003849 AllianceGenome:MGI:103187
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dtd; Ox1; Qr1; Dia4; Nmo1; Ox-1; Nmo-1; Nmor1
Summary: Enables NAD(P)H dehydrogenase (quinone) activity and NADH:ubiquinone reductase (non-electrogenic) activity. Involved in several processes, including protein polyubiquitination; response to lipopolysaccharide; and vitamin K metabolic process. Acts upstream of or within negative regulation of catalytic activity and response to oxidative stress. Is active in cytoplasm and nucleus. Is expressed in heart; liver; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 86.2), bladder adult (RPKM 36.2) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 54.08 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (108114856..108139012, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (107388225..107403205, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
Title: Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
Title: Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway.
Title: Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway.
Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels.
Title: Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels.
NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Title: NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy.
Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance.
Title: Activation of AhR-NQO1 Signaling Pathway Protects Against Alcohol-Induced Liver Injury by Improving Redox Balance.
Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth.
Title: Docosahexanoic acid signals through the Nrf2-Nqo1 pathway to maintain redox balance and promote neurite outgrowth.
A redox-mediated conformational change in NQO1 controls binding to microtubules and alpha-tubulin acetylation.
Title: A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation.
NQO1 regulates pharmaco-behavioral effects of d-amphetamine in striatal dopaminergic system in mice.
Title: NQO1 regulates pharmaco-behavioral effects of d-amphetamine in striatal dopaminergic system in mice.
beta-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease.
Title: β-Caryophyllene exerts protective antioxidant effects through the activation of NQO1 in the MPTP model of Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV001255 (e-PCR)
- UniSTS:179814

Nqo1 (e-PCR), detects polymorphism
- UniSTS:499103

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD(P)H dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD(P)H dehydrogenase (quinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD(P)H dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH:ubiquinone reductase (non-electrogenic) activity	IDA Inferred from Direct Assay more info	PubMed
enables NADH:ubiquinone reductase (non-electrogenic) activity	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADH oxidation	ISO Inferred from Sequence Orthology more info
involved_in NADPH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADPH oxidation	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to metal ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ferroptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to L-glutamine	IEA Inferred from Electronic Annotation more info
involved_in response to L-glutamine	ISO Inferred from Sequence Orthology more info
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in response to amine	IEA Inferred from Electronic Annotation more info
involved_in response to amine	ISO Inferred from Sequence Orthology more info
involved_in response to carbohydrate	IEA Inferred from Electronic Annotation more info
involved_in response to electrical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to flavonoid	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen sulfide	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in response to tetrachloromethane	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vitamin E metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin E metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in vitamin K metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NAD(P)H dehydrogenase [quinone] 1

Names: DT-diaphorase; NAD(P)H dehydrogenase (quinone); NAD(P)H menadione oxidoreductase 1, dioxin inducible; NAD(P)H:quinone oxidoreductase 1; azoreductase; diaphorase 4 (NADH/NADPH); menadione reductase; phylloquinone reductase; quinone reductase 1

NP_032732.3

EC 1.6.5.2

XP_036009703.1

EC 1.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008706.5 → NP_032732.3 NAD(P)H dehydrogenase [quinone] 1

See identical proteins and their annotated locations for NP_032732.3

Status: VALIDATED

Source sequence(s)

AA982077, AK075568

Consensus CDS

CCDS40465.1

UniProtKB/Swiss-Prot

Q64669

UniProtKB/TrEMBL

Q542Y0, Q99KL8

Related

ENSMUSP00000003947.9, ENSMUST00000003947.9

Conserved Domains (1) summary

pfam02525
Location:5 → 212

Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

108114856..108139012 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153810.1 → XP_036009703.1 NAD(P)H dehydrogenase [quinone] 1 isoform X1

UniProtKB/Swiss-Prot

Q64669

UniProtKB/TrEMBL

Q542Y0, Q99KL8

Conserved Domains (1) summary

pfam02525
Location:5 → 212

Flavodoxin_2; Flavodoxin-like fold