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    Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [ Mus musculus (house mouse) ]

    Gene ID: 56709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajb12provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B12provided by MGI
    Primary source
    MGI:MGI:1931881
    See related
    Ensembl:ENSMUSG00000020109 AllianceGenome:MGI:1931881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj10; mDj10
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including ERAD pathway; cellular response to misfolded protein; and chaperone cofactor-dependent protein refolding. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.5), adrenal adult (RPKM 24.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajb12 in Genome Data Viewer
    Location:
    10 B4; 10 29.64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59715405..59735118)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59879583..59899296)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake 1 Neighboring gene predicted gene, 23803 Neighboring gene STARR-seq mESC enhancer starr_26780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59342224-59342333 Neighboring gene predicted gene 7413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:59359601-59359774 Neighboring gene STARR-positive B cell enhancer ABC_E10610 Neighboring gene STARR-positive B cell enhancer ABC_E9340 Neighboring gene STARR-seq mESC enhancer starr_26783 Neighboring gene STARR-seq mESC enhancer starr_26784 Neighboring gene predicted gene, 46226 Neighboring gene STARR-seq mESC enhancer starr_26789 Neighboring gene predicted gene, 40673 Neighboring gene STARR-seq mESC enhancer starr_26790 Neighboring gene STARR-seq mESC enhancer starr_26791 Neighboring gene STARR-seq mESC enhancer starr_26792 Neighboring gene DNA-damage-inducible transcript 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
    2. Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Eisenhardt AE, et al. Oncotarget, 2016 May 3. PMID 27034005, Free PMC Article
    3. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to misfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 12
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 12
    DnaJ homolog 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374756.1 → NP_001361685.1  dnaJ homolog subfamily B member 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      Consensus CDS
      CCDS88010.1
      UniProtKB/TrEMBL
      Q8C4C9
      Related
      ENSMUSP00000116577.2, ENSMUST00000147914.8
      Conserved Domains (2) summary
      TIGR02349
      Location:111 → 237
      DnaJ_bact; chaperone protein DnaJ
      pfam09320
      Location:269 → 369
      DUF1977; Domain of unknown function (DUF1977)

    2. NM_001376970.1 → NP_001363899.1  dnaJ homolog subfamily B member 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      UniProtKB/Swiss-Prot
      Q8K037, Q9QYI4
      Related
      ENSMUSP00000020309.7, ENSMUST00000020309.7

    3. NM_019965.3 → NP_064349.2  dnaJ homolog subfamily B member 12 isoform 2

      See identical proteins and their annotated locations for NP_064349.2

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      Consensus CDS
      CCDS23867.1
      UniProtKB/Swiss-Prot
      Q8K037, Q9QYI4
      Related
      ENSMUSP00000122056.2, ENSMUST00000146590.8
      Conserved Domains (2) summary
      pfam00226
      Location:111 → 172
      DnaJ; DnaJ domain
      pfam09320
      Location:269 → 369
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      59715405..59735118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYI4.2 GenPept UniProtKB/Swiss-Prot:Q9QYI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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