Prss22 serine protease 22 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss22provided by MGI
Official Full Name: serine protease 22provided by MGI
Primary source: MGI:MGI:1918085
See related: Ensembl:ENSMUSG00000045027 AllianceGenome:MGI:1918085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BSSP-4; SP001LA; 4733401N09Rik
Summary: Predicted to enable peptidase activator activity and serine-type endopeptidase activity. Predicted to be involved in positive regulation of peptidase activity and proteolysis. Predicted to be located in extracellular space. Is expressed in brain; eye; lung; reproductive system; and stomach. Orthologous to human PRSS22 (serine protease 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 6.1), stomach adult (RPKM 0.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.18 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24212508..24219696, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (23993534..24000722, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

4733401N09Rik (e-PCR), detects polymorphism
- UniSTS:265689

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of peptidase activity	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: brain-specific serine protease 4

Names: protease, serine 22; serine protease 26; tryptase epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133731.2 → NP_598492.2 brain-specific serine protease 4 precursor

See identical proteins and their annotated locations for NP_598492.2

Status: VALIDATED

Source sequence(s)

AB010778, AK014645, CD773447

Consensus CDS

CCDS37482.1

UniProtKB/Swiss-Prot

Q7TML0, Q9ER10

Related

ENSMUSP00000039808.7, ENSMUST00000041649.8

Conserved Domains (1) summary

cd00190
Location:50 → 288

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

24212508..24219696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524905.4 → XP_006524968.4 brain-specific serine protease 4 isoform X1

Conserved Domains (1) summary

cd00190
Location:108 → 346

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006524906.2 → XP_006524969.1 brain-specific serine protease 4 isoform X2

Conserved Domains (1) summary

cd00190
Location:4 → 232

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...