Mpp3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpp3provided by MGI
Official Full Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)provided by MGI
Primary source: MGI:MGI:1328354
See related: Ensembl:ENSMUSG00000052373 AllianceGenome:MGI:1328354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlgh3; 6430514B01
Summary: Predicted to enable PDZ domain binding activity. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including gut; metanephros; nasal cavity epithelium; nervous system; and retina. Orthologous to human MPP3 (MAGUK p55 scaffold protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 30.7), CNS E18 (RPKM 12.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101890488..101925854, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101999652..102027045, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data of this studysuggested that MPP3 is required for maintaining proper levels of PALS1 at the subapical region, and indicate that the MPP3 gene is a candidate modulator of the Crumbs complex.
Title: MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.
This study show that MPP3 is required for maintenance of the apical protein complex and adherens junctions and for stratification and proper migration of neurons during the development of the cortex.
Title: MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.
This indicates that, overall, interaction of 5-HT(2C) receptors with PDZ proteins inhibits receptor desensitization in cortical neurons.
Title: Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MAGUK p55 subfamily member 3

Names: Mpp3 membrane protein, palmitoylated 3; discs large homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403738.1 → NP_001390667.1 MAGUK p55 subfamily member 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/TrEMBL

Q6XE40
NM_001403739.1 → NP_001390668.1 MAGUK p55 subfamily member 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL591145
NM_001403740.1 → NP_001390669.1 MAGUK p55 subfamily member 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL591145
NM_001403742.1 → NP_001390671.1 MAGUK p55 subfamily member 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/TrEMBL

Q6XE40
NM_001403743.1 → NP_001390672.1 MAGUK p55 subfamily member 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL591145

UniProtKB/TrEMBL

Q6XE40
NM_001403744.1 → NP_001390673.1 MAGUK p55 subfamily member 3 isoform 4

Status: VALIDATED

Source sequence(s)

AL591145
NM_007863.3 → NP_031889.2 MAGUK p55 subfamily member 3 isoform 1

See identical proteins and their annotated locations for NP_031889.2

Status: VALIDATED

Source sequence(s)

AL591145

Consensus CDS

CCDS36338.1

UniProtKB/Swiss-Prot

E9Q5S2, O88910

UniProtKB/TrEMBL

Q6XE40

Related

ENSMUSP00000055469.5, ENSMUST00000062801.11

Conserved Domains (4) summary

smart00569
Location:71 → 121

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12039
Location:230 → 291

SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)

smart00072
Location:395 → 570

GuKc; Guanylate kinase homologues

cd00992
Location:135 → 215

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101890488..101925854 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156284.1 → XP_036012177.1 MAGUK p55 subfamily member 3 isoform X3

Conserved Domains (2) summary

smart00072
Location:235 → 410

GuKc; Guanylate kinase homologues

cl17036
Location:70 → 131

SH3; Src Homology 3 domain superfamily
XM_030245518.2 → XP_030101378.1 MAGUK p55 subfamily member 3 isoform X2

UniProtKB/Swiss-Prot

E9Q5S2, O88910

Conserved Domains (4) summary

smart00569
Location:3 → 53

L27; domain in receptor targeting proteins Lin-2 and Lin-7

cd12039
Location:162 → 223

SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)

smart00072
Location:327 → 502

GuKc; Guanylate kinase homologues

cd00992
Location:67 → 147

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...