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    Ermap erythroblast membrane-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 27028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ermapprovided by MGI
    Official Full Name
    erythroblast membrane-associated proteinprovided by MGI
    Primary source
    MGI:MGI:1349816
    See related
    Ensembl:ENSMUSG00000028644 AllianceGenome:MGI:1349816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Located in cytoplasmic vesicle. Is expressed in bone marrow; embryo; liver; and spleen. Orthologous to human ERMAP (erythroblast membrane associated protein (Scianna blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 85.9), liver E14.5 (RPKM 83.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ermap in Genome Data Viewer
    Location:
    4 D2.1; 4 55.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119032654..119047210, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119175457..119190013, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 1 Neighboring gene predicted gene 12867 Neighboring gene STARR-positive B cell enhancer ABC_E422 Neighboring gene zinc finger protein 691 Neighboring gene small vasohibin binding protein Neighboring gene transmembrane protein 269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses. Su M, et al. Cell Mol Immunol, 2021 Aug. PMID 32620788, Free PMC Article
    2. Cloning and characterization of human erythroid membrane-associated protein, human ERMAP. Xu H, et al. Genomics, 2001 Aug. PMID 11549310
    3. Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein. Ye TZ, et al. Gene, 2000 Jan 25. PMID 10721728
    4. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. McClelland KS, et al. Biol Reprod, 2015 Jun. PMID 25855264
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses.
      Title: ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    erythroid membrane-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369066.1 → NP_001355995.1  erythroid membrane-associated protein isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AL606975, BC063257
      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (3) summary
      pfam13851
      Location:267 → 316
      GAS; Growth-arrest specific micro-tubule binding
      cl02614
      Location:319 → 501
      SPRY; SPRY domain
      cl11960
      Location:41 → 141
      Ig; Immunoglobulin domain

    2. NM_013848.3 → NP_038876.3  erythroid membrane-associated protein isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL606975
      Consensus CDS
      CCDS18571.2
      UniProtKB/Swiss-Prot
      Q3UV82, Q6P4T5, Q8CEH1, Q9JLN5
      UniProtKB/TrEMBL
      A2A7P7
      Related
      ENSMUSP00000159033.2, ENSMUST00000239029.2
      Conserved Domains (3) summary
      pfam13851
      Location:269 → 318
      GAS; Growth-arrest specific micro-tubule binding
      cl02614
      Location:321 → 503
      SPRY; SPRY domain
      cl11960
      Location:41 → 141
      Ig; Immunoglobulin domain

    RNA

    1. NR_160957.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK036702, AL606975
      Related
      ENSMUST00000030396.15

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      119032654..119047210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503138.5 → XP_006503201.1  erythroid membrane-associated protein isoform X1

      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (2) summary
      cl02614
      Location:381 → 563
      SPRY; SPRY domain
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    2. XM_006503140.4 → XP_006503203.1  erythroid membrane-associated protein isoform X3

      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (2) summary
      cl02614
      Location:361 → 543
      SPRY; SPRY domain
      cl11960
      Location:67 → 167
      Ig; Immunoglobulin domain

    3. XM_006503141.4 → XP_006503204.1  erythroid membrane-associated protein isoform X4

      See identical proteins and their annotated locations for XP_006503204.1

      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (2) summary
      cl02614
      Location:335 → 517
      SPRY; SPRY domain
      cl11960
      Location:41 → 141
      Ig; Immunoglobulin domain

    4. XM_006503139.4 → XP_006503202.1  erythroid membrane-associated protein isoform X2

      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (3) summary
      cd15813
      Location:367 → 549
      SPRY_PRY_TRIM20; PRY/SPRY domain in tripartite motif-binding protein 20 (TRIM20), also known as pyrin
      pfam13851
      Location:315 → 364
      GAS; Growth-arrest specific micro-tubule binding
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    5. XM_030253591.1 → XP_030109451.1  erythroid membrane-associated protein isoform X4

      UniProtKB/TrEMBL
      A2A7P7
      Conserved Domains (2) summary
      cl02614
      Location:335 → 517
      SPRY; SPRY domain
      cl11960
      Location:41 → 141
      Ig; Immunoglobulin domain

    6. XM_006503143.4 → XP_006503206.1  erythroid membrane-associated protein isoform X5

      UniProtKB/TrEMBL
      E9QKE5
      Conserved Domains (1) summary
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    7. XM_006503144.5 → XP_006503207.1  erythroid membrane-associated protein isoform X7

      UniProtKB/TrEMBL
      E9QKE5
      Conserved Domains (1) summary
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    8. XM_017320248.3 → XP_017175737.1  erythroid membrane-associated protein isoform X8

      UniProtKB/TrEMBL
      E9QKE5
      Conserved Domains (1) summary
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    9. XM_011240548.3 → XP_011238850.1  erythroid membrane-associated protein isoform X6

      Conserved Domains (1) summary
      cl11960
      Location:87 → 187
      Ig; Immunoglobulin domain

    RNA

    1. XR_003954955.2 RNA Sequence

    2. XR_003954956.2 RNA Sequence

    3. XR_376323.4 RNA Sequence

    4. XR_867881.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLN5.2 GenPept UniProtKB/Swiss-Prot:Q9JLN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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