Nudt2 nudix hydrolase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudt2provided by MGI
Official Full Name: nudix hydrolase 2provided by MGI
Primary source: MGI:MGI:1913651
See related: Ensembl:ENSMUSG00000028443 AllianceGenome:MGI:1913651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: APAH1; 2310051L06Rik
Summary: Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 14.1), placenta adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 21.65 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41465085..41480926)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41465081..41480926)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
Title: NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta
Title: Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Names: ap4A hydrolase; ap4Aase; bis(5'-nucleosyl)-tetraphosphatase; diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; nudix motif 2

NP_079815.2

EC 3.6.1.17

XP_006538228.1

EC 3.6.1.17

XP_011248384.1

EC 3.6.1.17

XP_030109557.1

EC 3.6.1.17

XP_036020201.1

EC 3.6.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025539.2 → NP_079815.2 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

See identical proteins and their annotated locations for NP_079815.2

Status: VALIDATED

Source sequence(s)

AK018771, AK132532, CB845734

Consensus CDS

CCDS18061.1

UniProtKB/Swiss-Prot

P56380, Q9D2U6, Q9D6V2

UniProtKB/TrEMBL

Q3V1C8

Related

ENSMUSP00000030154.7, ENSMUST00000030154.7

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

41465085..41480926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164308.1 → XP_036020201.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

UniProtKB/Swiss-Prot

P56380, Q9D2U6, Q9D6V2

UniProtKB/TrEMBL

Q3V1C8

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
XM_011250082.4 → XP_011248384.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

See identical proteins and their annotated locations for XP_011248384.1

UniProtKB/Swiss-Prot

P56380, Q9D2U6, Q9D6V2

UniProtKB/TrEMBL

Q3V1C8

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
XM_030253697.2 → XP_030109557.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

UniProtKB/Swiss-Prot

P56380, Q9D2U6, Q9D6V2

UniProtKB/TrEMBL

Q3V1C8

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
XM_006538165.4 → XP_006538228.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

See identical proteins and their annotated locations for XP_006538228.1

UniProtKB/Swiss-Prot

P56380, Q9D2U6, Q9D6V2

UniProtKB/TrEMBL

Q3V1C8

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...