Tbxas1 thromboxane A synthase 1, platelet [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbxas1provided by MGI
Official Full Name: thromboxane A synthase 1, plateletprovided by MGI
Primary source: MGI:MGI:98497
See related: Ensembl:ENSMUSG00000029925 AllianceGenome:MGI:98497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TS; TXS; CYP5; THAS; TXAS; CYP5A1
Summary: Enables thromboxane-A synthase activity. Predicted to be involved in intracellular chloride ion homeostasis; positive regulation of vasoconstriction; and prostaglandin biosynthetic process. Predicted to be located in cytosol and endoplasmic reticulum membrane. Is expressed in several structures, including bone marrow; brain; liver; lung; and metanephros. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome and cerebral infarction. Orthologous to human TBXAS1 (thromboxane A synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 4.2), spleen adult (RPKM 3.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 17.85 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (38817897..39061524)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (38864159..39084590)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
Title: Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis.
this study shows that genetic depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular dysfunction in ischemia reperfusion injury
Title: Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor Signalling Prevents Microvascular Dysfunction in Ischaemia/Reperfusion Injury.
the administration of salted drinking water (2.7% NaCl) to wild-type mice resulted in elevated placental TXA2 synthase (TXAS) and plasma thromboxane A2, but not prostacyclin, levels, which was also found in clinical preeclampsia placenta samples.
Title: Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy.
12-HHT is produced by both TxAS-dependent and TxAS-independent pathways in vitro and in vi
Title: Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand.
TXAS mRNA expression was increased within the vascular wall in mouse models of atherosclerosis with advanced lesions.
Title: Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion.
thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition
Title: Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition.
minimal level of protein kinase A activity is required for the steroidogenic effect of the TBXAS inhibitor and that inhibition of TBXAS activity or its expression increase the steroidogenic sensitivity of MA-10 mouse Leydig cells to cAMP stimulation
Title: Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Markers

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:547156

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:265585

D6Mit90 (e-PCR), detects polymorphism
- UniSTS:116604

NoName (e-PCR)
- UniSTS:235418

L18868 (e-PCR)
- UniSTS:179362

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:144551

Tbxas1 (e-PCR), detects polymorphism
- UniSTS:463026

MHAa30g3.seq (e-PCR)
- UniSTS:125130

L18868 (e-PCR)
- UniSTS:124878

D6Mit222 (e-PCR), detects polymorphism
- UniSTS:130770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 12-hydroxyheptadecatrienoic acid synthase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables hydroperoxy icosatetraenoate dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables thromboxane-A synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thromboxane-A synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thromboxane-A synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to fatty acid	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thromboxane-A synthase

Names: TXA synthase; cytochrome P450 5A1; hydroperoxy icosatetraenoate dehydratase; thromboxane synthase

NP_001397404.1

EC 4.2.1.152

EC 5.3.99.5

NP_001397405.1

EC 4.2.1.152

EC 5.3.99.5

NP_001397406.1

EC 4.2.1.152

EC 5.3.99.5

NP_035669.3

EC 4.2.1.152

EC 5.3.99.5

XP_006505939.1

EC 4.2.1.152

EC 5.3.99.5

XP_006505942.1

EC 4.2.1.152

EC 5.3.99.5

XP_006505943.1

EC 4.2.1.152

EC 5.3.99.5

XP_006505944.1

EC 4.2.1.152

EC 5.3.99.5

XP_011239582.1

EC 4.2.1.152

EC 5.3.99.5

XP_017176988.1

EC 4.2.1.152

EC 5.3.99.5

XP_017176989.1

EC 4.2.1.152

EC 5.3.99.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410475.1 → NP_001397404.1 thromboxane-A synthase isoform 2

Status: VALIDATED

Source sequence(s)

AC125327, AC154016
NM_001410476.1 → NP_001397405.1 thromboxane-A synthase isoform 3

Status: VALIDATED

Source sequence(s)

AC125327, AC154016
NM_001410477.1 → NP_001397406.1 thromboxane-A synthase isoform 4

Status: VALIDATED

Source sequence(s)

AC125327, AC154016
NM_011539.4 → NP_035669.3 thromboxane-A synthase isoform 1

See identical proteins and their annotated locations for NP_035669.3

Status: VALIDATED

Source sequence(s)

AC125327, AC154016

Consensus CDS

CCDS20018.1

UniProtKB/Swiss-Prot

P36423, P97505

UniProtKB/TrEMBL

Q8K320

Related

ENSMUSP00000003017.7, ENSMUST00000003017.13

Conserved Domains (1) summary

pfam00067
Location:47 → 528

p450; Cytochrome P450

RNA

NR_177077.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC125327, AC154016

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

38817897..39061524

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321499.3 → XP_017176988.1 thromboxane-A synthase isoform X1

UniProtKB/Swiss-Prot

P36423, P97505

UniProtKB/TrEMBL

Q8K320

Conserved Domains (1) summary

pfam00067
Location:47 → 528

p450; Cytochrome P450
XM_017321500.3 → XP_017176989.1 thromboxane-A synthase isoform X1

UniProtKB/Swiss-Prot

P36423, P97505

UniProtKB/TrEMBL

Q8K320

Conserved Domains (1) summary

pfam00067
Location:47 → 528

p450; Cytochrome P450
XM_011241280.4 → XP_011239582.1 thromboxane-A synthase isoform X1

See identical proteins and their annotated locations for XP_011239582.1

UniProtKB/Swiss-Prot

P36423, P97505

UniProtKB/TrEMBL

Q8K320

Conserved Domains (1) summary

pfam00067
Location:47 → 528

p450; Cytochrome P450
XM_006505881.4 → XP_006505944.1 thromboxane-A synthase isoform X7

UniProtKB/TrEMBL

Q3UTF0

Conserved Domains (1) summary

cl12078
Location:47 → 378

p450; Cytochrome P450
XM_006505879.5 → XP_006505942.1 thromboxane-A synthase isoform X5

UniProtKB/TrEMBL

Q3UTF0

Conserved Domains (1) summary

cl12078
Location:47 → 455

p450; Cytochrome P450
XM_006505876.4 → XP_006505939.1 thromboxane-A synthase isoform X2

UniProtKB/TrEMBL

Q8K320

Conserved Domains (1) summary

pfam00067
Location:47 → 528

p450; Cytochrome P450
XM_006505880.5 → XP_006505943.1 thromboxane-A synthase isoform X6

Conserved Domains (1) summary

pfam00067
Location:6 → 410

p450; Cytochrome P450