Tub TUB bipartite transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tubprovided by MGI
Official Full Name: TUB bipartite transcription factorprovided by MGI
Primary source: MGI:MGI:2651573
See related: Ensembl:ENSMUSG00000031028 AllianceGenome:MGI:2651573
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: rd5; tub
Summary: Predicted to enable G protein-coupled receptor binding activity and intraciliary transport particle A binding activity. Acts upstream of or within several processes, including phagocytosis, recognition; photoreceptor cell maintenance; and protein localization to non-motile cilium. Located in cytosol and extracellular region. Is expressed in several structures, including central nervous system; endocrine gland; musculature; peripheral nervous system; and sensory organ. Used to study obesity. Orthologous to human TUB (TUB bipartite transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 40.9), whole brain E14.5 (RPKM 30.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.21 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (108610087..108633666)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (109010880..109034459)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia.
Title: Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia.
TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments.
Title: TULP1 and TUB Are Required for Specific Localization of PRCD to Photoreceptor Outer Segments.
We found that the mutant Tub proteins were mostly localized to puncta found in the perinuclear region and that the C-terminus was important for its solubility. our results suggest that the malfunctions of the Tub mutant are caused by its misfolding and subsequent localization to aggresomes.
Title: C-terminally mutated tubby protein accumulates in aggresomes.
These results suggest that tubby is a ligand to facilitate microglial phagocytosis through MerTK for the maintenance of CNS homeostasis.
Title: Tubby regulates microglial phagocytosis through MerTK.
Mtap1a, which modifies hearing loss in Tub(tub/tub) mice, also modifies retinal degeneration in Tub and Tulp1 mice; functionally nonredundant members of the TULP family (TUB and TULP1) share a common functional interaction with MTAP1A
Title: An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice.
TUB plays a role in insulin signalling and fuel homeostasis in adipocytes.
Title: Expression and modulation of TUB by insulin and thyroid hormone in primary rat and murine 3T3-L1 adipocytes.
Tubby and Tulp1 function as phagocytosis sigmals (eat-me) for retinal pigment epithelium cells and other phagocytes.
Title: Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.
Tubby secretion is partially dependent on its PI(4,5)P(2)-binding activity with an essential secretory signal in the N-terminus.
Title: Unconventional secretion of tubby and tubby-like protein 1.
Data show that agouti-related protein mRNA levels are significantly lower in obese tub/tub mice as compared to tub/+ mice.
Title: Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Spontaneous (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

tub (e-PCR), detects polymorphism
- UniSTS:144699

tub (e-PCR), detects polymorphism
- UniSTS:144700

NoName (e-PCR)
- UniSTS:235740

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables intraciliary transport particle A binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intraciliary transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoreceptor cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to photoreceptor outer segment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubby protein

Names: retinal degeneration 5; tubby bipartite transcription factor; tubby candidate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.