Mink1 misshapen-like kinase 1 (zebrafish) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mink1provided by MGI
Official Full Name: misshapen-like kinase 1 (zebrafish)provided by MGI
Primary source: MGI:MGI:1355329
See related: Ensembl:ENSMUSG00000020827 AllianceGenome:MGI:1355329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B55; MINK; Ysk2; Map4k6
Summary: Enables ATP binding activity and protein serine/threonine kinase activity. Involved in brain development; positive regulation of MAPK cascade; and protein phosphorylation. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in knee joint primordium; knee mesenchyme; lower leg mesenchyme; tibia; and tibia cartilage condensation. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 44.5), frontal lobe adult (RPKM 42.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 43.0 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70452272..70505309)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70561580..70614482)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Title: MINK1 deficiency stimulates nucleus pulposus cell pyroptosis and exacerbates intervertebral disc degeneration.
Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling.
Title: Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFβ signaling.
a critical regulator of Th17 cell differentiation
Title: Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1.
using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing
Title: Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.
MINK1 may be an important signaling molecule that mediates mitogen-activated protein kinase signaling and participates in platelet activation and thrombus formation.
Title: Misshapen/NIK-related kinase (MINK1) is involved in platelet function, hemostasis, and thrombus formation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21871-21872:1046872408:1 (e-PCR)
- UniSTS:268659

J04698 (e-PCR)
- UniSTS:124855

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendrite morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: misshapen-like kinase 1

Names: GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIKs-related kinase; Yeast Sps1/Ste20-related kinase 2; misshapen/NIK-related kinase

NP_001039424.1

EC 2.7.11.1

NP_001039429.1

EC 2.7.11.1

NP_001390484.1

EC 2.7.11.1

NP_001390485.1

EC 2.7.11.1

NP_001390486.1

EC 2.7.11.1

NP_057922.2

EC 2.7.11.1

NP_795712.2

EC 2.7.11.1

XP_006533740.1

EC 2.7.11.1

XP_006533741.1

EC 2.7.11.1

XP_017170134.1

EC 2.7.11.1

XP_017170135.1

EC 2.7.11.1

XP_030101977.1

EC 2.7.11.1

XP_030101978.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045959.2 → NP_001039424.1 misshapen-like kinase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL592547

Consensus CDS

CCDS36205.1

UniProtKB/TrEMBL

Q5SXG1, Q5SXG3

Related

ENSMUSP00000072649.8, ENSMUST00000072873.14

Conserved Domains (3) summary

smart00036
Location:1019 → 1317

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
NM_001045964.2 → NP_001039429.1 misshapen-like kinase 1 isoform 4

See identical proteins and their annotated locations for NP_001039429.1

Status: VALIDATED

Source sequence(s)

AL592547

Consensus CDS

CCDS48837.1

UniProtKB/TrEMBL

G3X9G2, Q5SXG1

Related

ENSMUSP00000072091.7, ENSMUST00000072237.13

Conserved Domains (3) summary

smart00036
Location:1026 → 1324

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
NM_001403555.1 → NP_001390484.1 misshapen-like kinase 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL592547

UniProtKB/TrEMBL

Q5SXG1
NM_001403556.1 → NP_001390485.1 misshapen-like kinase 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL592547

UniProtKB/TrEMBL

Q5SXG1
NM_001403557.1 → NP_001390486.1 misshapen-like kinase 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL592547

UniProtKB/TrEMBL

Q5SXG1
NM_016713.3 → NP_057922.2 misshapen-like kinase 1 isoform 1

See identical proteins and their annotated locations for NP_057922.2

Status: VALIDATED

Source sequence(s)

AL592547

Consensus CDS

CCDS24954.1

UniProtKB/TrEMBL

Q5SXG1

Related

ENSMUSP00000099618.5, ENSMUST00000102558.11

Conserved Domains (3) summary

smart00036
Location:982 → 1280

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
NM_176893.3 → NP_795712.2 misshapen-like kinase 1 isoform 2

See identical proteins and their annotated locations for NP_795712.2

Status: VALIDATED

Source sequence(s)

AL592547

Consensus CDS

CCDS24955.1

UniProtKB/Swiss-Prot

Q5SXG2, Q921M6, Q9JM52, Q9JM92

UniProtKB/TrEMBL

Q5SXG1

Related

ENSMUSP00000099619.5, ENSMUST00000102559.11

Conserved Domains (3) summary

smart00036
Location:990 → 1288

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

smart00220
Location:25 → 289

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70452272..70505309

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533677.4 → XP_006533740.1 misshapen-like kinase 1 isoform X1

See identical proteins and their annotated locations for XP_006533740.1

UniProtKB/TrEMBL

Q5SXG1

Conserved Domains (3) summary

smart00036
Location:1056 → 1354

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

PHA03307
Location:539 → 835

PHA03307; transcriptional regulator ICP4; Provisional

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
XM_006533678.4 → XP_006533741.1 misshapen-like kinase 1 isoform X2

See identical proteins and their annotated locations for XP_006533741.1

UniProtKB/TrEMBL

Q5SXG1

Conserved Domains (3) summary

smart00036
Location:1055 → 1353

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

PHA03307
Location:539 → 835

PHA03307; transcriptional regulator ICP4; Provisional

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
XM_017314645.3 → XP_017170134.1 misshapen-like kinase 1 isoform X6

UniProtKB/TrEMBL

Q5SXG1

Conserved Domains (2) summary

smart00036
Location:1018 → 1316

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
XM_017314646.3 → XP_017170135.1 misshapen-like kinase 1 isoform X7

UniProtKB/TrEMBL

Q5SXG1

Conserved Domains (2) summary

smart00036
Location:1011 → 1309

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
XM_030246117.2 → XP_030101977.1 misshapen-like kinase 1 isoform X8

UniProtKB/TrEMBL

Q5SXG1

Conserved Domains (3) summary

smart00036
Location:981 → 1279

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

PHA03307
Location:515 → 788

PHA03307; transcriptional regulator ICP4; Provisional

cd06636
Location:8 → 289

STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
XM_030246118.1 → XP_030101978.1 misshapen-like kinase 1 isoform X9

UniProtKB/TrEMBL

F7AMS7

Conserved Domains (2) summary

smart00036
Location:745 → 1043

CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2

PHA03307
Location:228 → 524

PHA03307; transcriptional regulator ICP4; Provisional