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    Thap4 THAP domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 67026, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Thap4provided by MGI
    Official Full Name
    THAP domain containing 4provided by MGI
    Primary source
    MGI:MGI:1914276
    See related
    Ensembl:ENSMUSG00000026279 AllianceGenome:MGI:1914276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nb(III); 2010320B01Rik
    Summary
    Predicted to enable several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Predicted to be involved in nitrate metabolic process and tyrosine metabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina nuclear layer; and submandibular gland primordium. Orthologous to human THAP4 (THAP domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 55.8), kidney adult (RPKM 23.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thap4 in Genome Data Viewer
    Location:
    1 D; 1 47.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93633113..93682560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93705391..93754838, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95532366-95532549 Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene STARR-seq mESC enhancer starr_01735 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene deoxythymidylate kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice. Katayama K, et al. Mamm Genome, 2024 Jun. PMID 38658415
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
      Title: Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitric oxide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitric oxide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peroxynitrite isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxynitrite isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tyrosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tyrosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxynitrite isomerase THAP4
    Names
    THAP domain-containing protein 4
    ferric nitrobindin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310761.1 → NP_001297690.1  peroxynitrite isomerase THAP4 isoform 2

      See identical proteins and their annotated locations for NP_001297690.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons and contains an alternate 5' exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC131316, AK167814, BE863103
      Consensus CDS
      CCDS78657.1
      UniProtKB/TrEMBL
      A0A0J9YU08
      Related
      ENSMUSP00000143943.2, ENSMUST00000189728.7
      Conserved Domains (1) summary
      cd07828
      Location:10 → 162
      nitrobindin; nitrobindin heme-binding domain

    2. NM_025920.3 → NP_080196.3  peroxynitrite isomerase THAP4 isoform 1

      See identical proteins and their annotated locations for NP_080196.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK167814, BC066042
      Consensus CDS
      CCDS15194.1
      UniProtKB/Swiss-Prot
      Q3US28, Q6NZN6, Q6P3Z3, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3
      Related
      ENSMUSP00000140761.2, ENSMUST00000190116.7
      Conserved Domains (4) summary
      smart00980
      Location:4 → 85
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
      PHA03307
      Location:123 → 314
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam09486
      Location:342 → 389
      HrpB7; Bacterial type III secretion protein (HrpB7)
      cd07828
      Location:414 → 567
      lipocalin_heme-bd-THAP4-like; heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93633113..93682560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3Z3.1 GenPept UniProtKB/Swiss-Prot:Q6P3Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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