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    Eif3d eukaryotic translation initiation factor 3, subunit D [ Mus musculus (house mouse) ]

    Gene ID: 55944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif3dprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Dprovided by MGI
    Primary source
    MGI:MGI:1933181
    See related
    Ensembl:ENSMUSG00000016554 AllianceGenome:MGI:1933181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif3s7; eIF3p66; 66/67kDa
    Summary
    Contributes to translation initiation factor activity. Involved in formation of cytoplasmic translation initiation complex. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is active in synapse. Is expressed in embryo. Orthologous to human EIF3D (eukaryotic translation initiation factor 3 subunit D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 66.6), liver E14 (RPKM 65.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif3d in Genome Data Viewer
    Location:
    15 E1; 15 36.92 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77843201..77855006, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77958998..77970824, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E479 Neighboring gene thioredoxin 2 Neighboring gene FAD-dependent oxidoreductase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3146 Neighboring gene calcium channel, voltage-dependent, gamma subunit 2 Neighboring gene predicted gene, 46520 Neighboring gene STARR-seq mESC enhancer starr_39138 Neighboring gene RIKEN cDNA A730060N03 gene Neighboring gene STARR-positive B cell enhancer mm9_chr15:77950201-77950501

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Fujii K, et al. Dev Cell, 2021 Nov 8. PMID 34752747, Free PMC Article
    2. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article
    3. Reconstitution reveals the functional core of mammalian eIF3. Masutani M, et al. EMBO J, 2007 Jul 25. PMID 17581632, Free PMC Article
    4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    5. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC115774

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA cap binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cap-dependent translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cap-dependent translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral translational termination-reinitiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational termination-reinitiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit D
    Names
    eIF-3-zeta
    eIF3 p66
    eukaryotic translation initiation factor 3 subunit 7
    eukaryotic translation initiation factor 3, subunit 7 (zeta)
    translation initiation factor eIF3 p66

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411926.1 → NP_001398855.1  eukaryotic translation initiation factor 3 subunit D

      Status: VALIDATED

      Source sequence(s)
      AL589650
      UniProtKB/Swiss-Prot
      O70194, Q8BLH0, Q8BWW1

    2. NM_018749.3 → NP_061219.2  eukaryotic translation initiation factor 3 subunit D

      See identical proteins and their annotated locations for NP_061219.2

      Status: VALIDATED

      Source sequence(s)
      AL589650
      Consensus CDS
      CCDS37130.1
      UniProtKB/Swiss-Prot
      O70194, Q8BLH0, Q8BWW1
      Related
      ENSMUSP00000098053.5, ENSMUST00000100484.6
      Conserved Domains (1) summary
      pfam05091
      Location:4 → 521
      eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      77843201..77855006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70194.2 GenPept UniProtKB/Swiss-Prot:O70194

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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