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    Ctdspl2 CTD small phosphatase like 2 [ Mus musculus (house mouse) ]

    Gene ID: 329506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctdspl2provided by MGI
    Official Full Name
    CTD small phosphatase like 2provided by MGI
    Primary source
    MGI:MGI:1196405
    See related
    Ensembl:ENSMUSG00000033411 AllianceGenome:MGI:1196405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCP4; D2Ertd485e
    Summary
    Enables phosphoprotein phosphatase activity. Acts upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleus. Is expressed in several structures, including adrenal gland; brain; gallbladder; genitourinary system; and gut. Orthologous to human CTDSPL2 (CTD small phosphatase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.0), CNS E11.5 (RPKM 6.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctdspl2 in Genome Data Viewer
    Location:
    2 E5; 2 60.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121785879..121845807)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121955398..122015326)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05541 Neighboring gene golgi membrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_05542 Neighboring gene STARR-seq mESC enhancer starr_05544 Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene predicted gene, 39916 Neighboring gene MAGE family member B3 Neighboring gene STARR-positive B cell enhancer ABC_E1597 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene beta-2 microglobulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Cao J, et al. Diabetes, 2018 Jan. PMID 28851713, Free PMC Article
    2. Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation. Wang P, et al. Cell Prolif, 2024 Sep. PMID 38886174, Free PMC Article
    3. The nuclear phosphatase SCP4 regulates FoxO transcription factors during muscle wasting in chronic kidney disease. Liu X, et al. Kidney Int, 2017 Aug. PMID 28506762, Free PMC Article
    4. C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation. Zhao Y, et al. J Biol Chem, 2014 Sep 19. PMID 25100727, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation.
      Title: Protein phosphatase SCP4 regulates cartilage development and endochondral osteogenesis via FoxO3a dephosphorylation.
    2. regulator of FoxO transcription factors and promotes cellular proteolysis
      Title: The nuclear phosphatase SCP4 regulates FoxO transcription factors during muscle wasting in chronic kidney disease.
    3. SCP4, is a Smad phosphatase and plays a critical role in BMP-induced signaling and cellular functions.
      Title: C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CTD small phosphatase-like protein 2
    Names
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
    CTDSP-like 2
    NP_001277920.1
    NP_001277921.1
    NP_997615.1
    XP_011237929.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290991.1 → NP_001277920.1  CTD small phosphatase-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001277920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      AK039162, AK053513, AK163262, BB183048
      Consensus CDS
      CCDS71130.1
      UniProtKB/Swiss-Prot
      Q8BG15
      Related
      ENSMUSP00000106207.2, ENSMUST00000110578.8
      Conserved Domains (1) summary
      TIGR02251
      Location:285 → 446
      HIF-SF_euk; Dullard-like phosphatase domain

    2. NM_001290992.1 → NP_001277921.1  CTD small phosphatase-like protein 2 isoform c

      See identical proteins and their annotated locations for NP_001277921.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK033382, AK039162, AK163262, BB183048
      UniProtKB/Swiss-Prot
      Q8BG15
      Conserved Domains (1) summary
      TIGR02251
      Location:172 → 327
      HIF-SF_euk; Dullard-like phosphatase domain

    3. NM_212450.4 → NP_997615.1  CTD small phosphatase-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_997615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK033382, AK039162, AK163262, BB183048
      Consensus CDS
      CCDS16652.1
      UniProtKB/Swiss-Prot
      A2ARL6, Q3TF86, Q3TQW7, Q3TV36, Q7TPZ9, Q8BG15, Q8BPR3, Q8C9S0, Q8CEG6
      Related
      ENSMUSP00000047543.7, ENSMUST00000036647.13
      Conserved Domains (1) summary
      TIGR02251
      Location:286 → 447
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121785879..121845807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239627.3 → XP_011237929.1  CTD small phosphatase-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011237929.1

      Conserved Domains (1) summary
      cl21460
      Location:286 → 322
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. XR_001783138.2 RNA Sequence

    2. XR_003953663.1 RNA Sequence

    3. XR_003953664.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG15.1 GenPept UniProtKB/Swiss-Prot:Q8BG15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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