Hinfp histone H4 transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hinfpprovided by MGI
Official Full Name: histone H4 transcription factorprovided by MGI
Primary source: MGI:MGI:2429620
See related: Ensembl:ENSMUSG00000032119 AllianceGenome:MGI:2429620
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mizf; HiNF-P
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in DNA-templated transcription; in utero embryonic development; and regulation of gene expression. Predicted to be located in Cajal body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.6), CNS E14 (RPKM 5.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44201509..44217003, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44292438..44305716, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression.
Title: Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos.
simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation.
Title: p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency.
Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage.
Title: Fidelity of histone gene regulation is obligatory for genome replication and stability.
The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.
Title: Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.
Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
The dependence of HiNF-P gene transcription on cyclin E/CDK2/p220NPAT signaling defines a novel feed-forward loop that may sustain HiNF-P expression in proliferating cells to support the cell cycle regulated synthesis of histone H4 proteins.
Title: Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hinfp (e-PCR), detects polymorphism
- UniSTS:545849

AA589481 (e-PCR)
- UniSTS:179885

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Cajal body	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histone H4 transcription factor

Names: MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein; MBD2-interacting zinc finger protein; histone nuclear factor P; methyl-CpG-binding protein 2-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405064.1 → NP_001391993.1 histone H4 transcription factor

Status: VALIDATED

Source sequence(s)

AC124577

UniProtKB/Swiss-Prot

E9QPQ4, Q8BWY0, Q8K1K9

UniProtKB/TrEMBL

Q4FK13
NM_001405065.1 → NP_001391994.1 histone H4 transcription factor

Status: VALIDATED

Source sequence(s)

AC124577

UniProtKB/Swiss-Prot

E9QPQ4, Q8BWY0, Q8K1K9

UniProtKB/TrEMBL

Q4FK13

Related

ENSMUSP00000034629.6, ENSMUST00000034629.6
NM_001405066.1 → NP_001391995.1 histone H4 transcription factor

Status: VALIDATED

Source sequence(s)

AC124577

UniProtKB/Swiss-Prot

E9QPQ4, Q8BWY0, Q8K1K9

UniProtKB/TrEMBL

Q4FK13
NM_172162.4 → NP_751894.2 histone H4 transcription factor

See identical proteins and their annotated locations for NP_751894.2

Status: VALIDATED

Source sequence(s)

AC124577

Consensus CDS

CCDS23102.1

UniProtKB/Swiss-Prot

E9QPQ4, Q8BWY0, Q8K1K9

UniProtKB/TrEMBL

Q4FK13

Related

ENSMUSP00000149879.2, ENSMUST00000216508.2

Conserved Domains (2) summary

COG5048
Location:224 → 377

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:282 → 302

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44201509..44217003 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242379.3 → XP_011240681.1 histone H4 transcription factor isoform X2

See identical proteins and their annotated locations for XP_011240681.1

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011242378.4 → XP_011240680.1 histone H4 transcription factor isoform X2

See identical proteins and their annotated locations for XP_011240680.1

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006509897.5 → XP_006509960.1 histone H4 transcription factor isoform X3

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:231 → 384

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 309

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030243934.2 → XP_030099794.1 histone H4 transcription factor isoform X2

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011242376.4 → XP_011240678.1 histone H4 transcription factor isoform X1

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:240 → 393

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:298 → 318

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036154502.1 → XP_036010395.1 histone H4 transcription factor isoform X2

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030243935.2 → XP_030099795.1 histone H4 transcription factor isoform X4

UniProtKB/Swiss-Prot

E9QPQ4, Q8BWY0, Q8K1K9

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:224 → 377

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:282 → 302

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030243933.2 → XP_030099793.1 histone H4 transcription factor isoform X2

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011242377.4 → XP_011240679.1 histone H4 transcription factor isoform X2

See identical proteins and their annotated locations for XP_011240679.1

UniProtKB/TrEMBL

Q4FK13

Conserved Domains (2) summary

COG5048
Location:233 → 386

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:291 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]