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    Garin1b golgi associated RAB2 interactor 1B [ Mus musculus (house mouse) ]

    Gene ID: 330277, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Garin1bprovided by MGI
    Official Full Name
    golgi associated RAB2 interactor 1Bprovided by MGI
    Primary source
    MGI:MGI:3032524
    See related
    Ensembl:ENSMUSG00000039742 AllianceGenome:MGI:3032524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm764; Fam71f1; GARI-L1; NYD-SP18
    Summary
    Involved in acrosome assembly and acrosome reaction. Located in Golgi apparatus. Orthologous to human GARIN1B (golgi associated RAB2 interactor 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 95.0) See more
    Orthologs
    human all
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    Genomic context

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    See Garin1b in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29313468..29336021)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29313469..29336022)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4814 Neighboring gene hypoxia inducible lipid droplet associated Neighboring gene golgi associated RAB2 interactor 1A Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29297688-29297797 Neighboring gene calumenin Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) Neighboring gene nuclear encoded tRNA proline 6 (anticodon AGG) Neighboring gene blue cone (S) opsin upstream regulatory region

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice. Morohoshi A, et al. Development, 2021 Nov 1. PMID 34714330, Free PMC Article
    2. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
      Title: FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC58790

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi-associated RAB2 interactor protein 1B
    Names
    Golgi associated RAB2 interactor protein 1B
    Golgi associated RAB2 interactor-like 1
    Golgi-associated Rab2B interactor-like 1
    family with sequence similarity 71, member F1
    protein FAM71F1
    testes development-related NYD-SP18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289663.1 → NP_001276592.1  Golgi-associated RAB2 interactor protein 1B isoform 1

      See identical proteins and their annotated locations for NP_001276592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC044807, AK133908, BC172086
      Consensus CDS
      CCDS80497.1
      UniProtKB/TrEMBL
      B7ZWJ6
      Related
      ENSMUSP00000126496.2, ENSMUST00000164560.8
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    2. NM_001289664.1 → NP_001276593.1  Golgi-associated RAB2 interactor protein 1B isoform 2

      See identical proteins and their annotated locations for NP_001276593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC044807, AK133908, BC172074
      Consensus CDS
      CCDS80498.1
      UniProtKB/TrEMBL
      B7XG46
      Related
      ENSMUSP00000132703.2, ENSMUST00000166462.2
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    3. NM_001289665.1 → NP_001276594.1  Golgi-associated RAB2 interactor protein 1B isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC044807, AK133908, BC172074
      UniProtKB/Swiss-Prot
      Q3UZD7
      UniProtKB/TrEMBL
      B7XG46
      Conserved Domains (1) summary
      pfam12480
      Location:111 → 176
      DUF3699; Protein of unknown function (DUF3699)

    4. NM_001411773.1 → NP_001398702.1  Golgi-associated RAB2 interactor protein 1B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC044807

    5. NM_001411774.1 → NP_001398703.1  Golgi-associated RAB2 interactor protein 1B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC044807

    6. NM_001411775.1 → NP_001398704.1  Golgi-associated RAB2 interactor protein 1B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC044807

    7. NM_207258.3 → NP_997141.2  Golgi-associated RAB2 interactor protein 1B isoform 3

      See identical proteins and their annotated locations for NP_997141.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC044807, AK133908
      Consensus CDS
      CCDS39451.1
      UniProtKB/Swiss-Prot
      B2RW23, Q3UZD7
      Related
      ENSMUSP00000087973.6, ENSMUST00000090487.12
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29313468..29336021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255471.1 → XP_030111331.1  Golgi-associated RAB2 interactor protein 1B isoform X7

      Conserved Domains (1) summary
      pfam12480
      Location:111 → 176
      DUF3699; Protein of unknown function (DUF3699)

    2. XM_006505128.4 → XP_006505191.1  Golgi-associated RAB2 interactor protein 1B isoform X5

      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    3. XM_017321651.1 → XP_017177140.1  Golgi-associated RAB2 interactor protein 1B isoform X1

      UniProtKB/TrEMBL
      B7ZWJ6
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    4. XM_017321652.1 → XP_017177141.1  Golgi-associated RAB2 interactor protein 1B isoform X2

      UniProtKB/TrEMBL
      B7XG46
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    5. XM_017321653.1 → XP_017177142.1  Golgi-associated RAB2 interactor protein 1B isoform X3

      UniProtKB/Swiss-Prot
      B2RW23, Q3UZD7
      Conserved Domains (1) summary
      pfam12480
      Location:143 → 208
      DUF3699; Protein of unknown function (DUF3699)

    6. XM_017321654.1 → XP_017177143.1  Golgi-associated RAB2 interactor protein 1B isoform X4

      Conserved Domains (1) summary
      pfam12480
      Location:111 → 176
      DUF3699; Protein of unknown function (DUF3699)

    7. XM_017321655.1 → XP_017177144.1  Golgi-associated RAB2 interactor protein 1B isoform X6

      Conserved Domains (1) summary
      pfam12480
      Location:54 → 116
      DUF3699; Protein of unknown function (DUF3699)

    8. XM_030255473.1 → XP_030111333.1  Golgi-associated RAB2 interactor protein 1B isoform X10

      Conserved Domains (1) summary
      pfam12480
      Location:54 → 116
      DUF3699; Protein of unknown function (DUF3699)

    9. XM_030255472.1 → XP_030111332.1  Golgi-associated RAB2 interactor protein 1B isoform X9

      Conserved Domains (1) summary
      pfam12480
      Location:111 → 176
      DUF3699; Protein of unknown function (DUF3699)

    10. XM_030255476.2 → XP_030111336.1  Golgi-associated RAB2 interactor protein 1B isoform X13

      Conserved Domains (1) summary
      pfam12480
      Location:111 → 176
      DUF3699; Protein of unknown function (DUF3699)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZD7.1 GenPept UniProtKB/Swiss-Prot:Q3UZD7

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