Ik IK cytokine [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikprovided by MGI
Official Full Name: IK cytokineprovided by MGI
Primary source: MGI:MGI:1345142
See related: Ensembl:ENSMUSG00000024474 AllianceGenome:MGI:1345142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MuRED
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in nucleus. Predicted to colocalize with mitotic spindle pole and nuclear chromosome. Is expressed in testis. Orthologous to human IK (IK cytokine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 65.1), CNS E14 (RPKM 39.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.46 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36877709..36890692)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36744656..36757639)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our observations suggest that tIK cytokine can counterbalance the induction of inflammatory cells related to rheumatoid arthritis(RA) and thus could be a new therapeutic agent for the treatment of RA.
Title: IK acts as an immunoregulator of inflammatory arthritis by suppressing T(H)17 cell differentiation and macrophage activation.
IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases
Title: Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.
Taken together, these results imply that IK plays a role in downregulating MHC class II expression on B cells during coxsackievirus B3 infection through the induction of cAMP.
Title: IK induced by coxsackievirus B3 infection transiently downregulates expression of MHC class II through increasing cAMP.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ik (e-PCR), detects polymorphism
- UniSTS:471091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of U2-type precatalytic spliceosome	ISO Inferred from Sequence Orthology more info
part_of U2-type precatalytic spliceosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with mitotic spindle pole	ISO Inferred from Sequence Orthology more info
colocalizes_with mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with nuclear chromosome	ISO Inferred from Sequence Orthology more info
colocalizes_with nuclear chromosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein Red

Names: IK factor; arginine/glutamic acid/aspartic acid repeat containing protein; cytokine IK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.