Helz2 helicase with zinc finger 2, transcriptional coactivator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Helz2provided by MGI
Official Full Name: helicase with zinc finger 2, transcriptional coactivatorprovided by MGI
Primary source: MGI:MGI:2385169
See related: Ensembl:ENSMUSG00000027580 AllianceGenome:MGI:2385169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PDIP1; mPDIP1; Pric285; mKIAA1769
Summary: Predicted to enable RNA binding activity; RNA helicase activity; and exoribonuclease II activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Predicted to be active in P granule and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and telencephalon. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 53.3), thymus adult (RPKM 35.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.63 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180869408..180883851, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (181227615..181242058, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SFPQ associated with a co-activator for PPARgamma, HELZ2, regulates key nuclear factors for adipocyte differentiation.
Title: SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation.
Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice.
Title: Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BC006779 (e-PCR), detects polymorphism
- UniSTS:547190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables exoribonuclease II activity	ISO Inferred from Sequence Orthology more info
enables exoribonuclease II activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 3'-5' exoribonuclease HELZ2

Names: ATP-dependent RNA helicase PRIC285; PPAR gamma-DNA-binding domain interacting protein1; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; helicase with zinc finger domain 2; peroxisomal proliferator-activated receptor A interacting complex 285

NP_898985.2

EC 3.1.13.1

EC 3.6.4.13

XP_006500662.1

EC 3.1.13.1

EC 3.6.4.13

XP_006500664.1

EC 3.1.13.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183162.2 → NP_898985.2 3'-5' exoribonuclease HELZ2

See identical proteins and their annotated locations for NP_898985.2

Status: VALIDATED

Source sequence(s)

AK157942, AK168622, AL845506, BF453182

Consensus CDS

CCDS38380.1

UniProtKB/Swiss-Prot

B9A0U1, E9QAM5

UniProtKB/TrEMBL

A2AS05

Related

ENSMUSP00000104459.2, ENSMUST00000108831.8

Conserved Domains (4) summary

smart00955
Location:1567 → 1924

RNB; This domain is the catalytic domain of ribonuclease II

cd18040
Location:2448 → 2724

DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2

pfam13087
Location:2704 → 2909

AAA_12; AAA domain

cl28899
Location:760 → 990

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180869408..180883851 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500601.3 → XP_006500664.1 3'-5' exoribonuclease HELZ2 isoform X2

UniProtKB/TrEMBL

A2AS03, A2AS05

Related

ENSMUSP00000091756.5, ENSMUST00000094203.11

Conserved Domains (4) summary

smart00955
Location:1567 → 1924

RNB; This domain is the catalytic domain of ribonuclease II

cd18040
Location:2448 → 2724

DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2

pfam13087
Location:2704 → 2909

AAA_12; AAA domain

cl28899
Location:760 → 990

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_006500599.3 → XP_006500662.1 3'-5' exoribonuclease HELZ2 isoform X1

See identical proteins and their annotated locations for XP_006500662.1

UniProtKB/Swiss-Prot

B9A0U1, E9QAM5

UniProtKB/TrEMBL

A2AS05

Related

ENSMUSP00000112917.2, ENSMUST00000121484.2

Conserved Domains (4) summary

smart00955
Location:1567 → 1924

RNB; This domain is the catalytic domain of ribonuclease II

cd18040
Location:2448 → 2724

DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2

pfam13087
Location:2704 → 2909

AAA_12; AAA domain

cl28899
Location:760 → 990

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily