Ptx4 pentraxin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptx4provided by MGI
Official Full Name: pentraxin 4provided by MGI
Primary source: MGI:MGI:1915759
See related: Ensembl:ENSMUSG00000044172 AllianceGenome:MGI:1915759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110018H23Rik
Summary: Predicted to enable metal ion binding activity. Predicted to be located in extracellular region. Orthologous to human PTX4 (pentraxin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25339328..25344256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25120697..25125293)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The long pentraxin Ptx4 discovered in this study reveals that the gene clusters alone in phylogenetic analysis, is well conserved from mammals to lower vertebrates and has a unique pattern of messenger RNA expression.
Title: Evolution of the pentraxin family: the new entry PTX4.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D10Got28 (e-PCR)
- UniSTS:115981

NoName (e-PCR)
- UniSTS:487895

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pentraxin-4

Names: neuronal pentraxin-like protein C16orf38 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163416.1 → NP_001156888.1 pentraxin-4 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC130711

Consensus CDS

CCDS89017.1

UniProtKB/Swiss-Prot

Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3

UniProtKB/TrEMBL

A0A3B2WCG1

Related

ENSMUSP00000156495.2, ENSMUST00000232902.2

Conserved Domains (1) summary

cl22861
Location:241 → 438

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_026747.1 → NP_081023.1 pentraxin-4 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC130711

Consensus CDS

CCDS50031.1

UniProtKB/Swiss-Prot

Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3

UniProtKB/TrEMBL

E9QNW3

Related

ENSMUSP00000055984.7, ENSMUST00000054930.7

Conserved Domains (1) summary

cl22861
Location:271 → 468

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25339328..25344256

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524845.4 → XP_006524908.1 pentraxin-4 isoform X1

UniProtKB/Swiss-Prot

Q08EL0, Q148B7, Q14BG6, Q6RUU0, Q9D1A3

Conserved Domains (1) summary

cl22861
Location:183 → 380

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...