Tpr translocated promoter region, nuclear basket protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tprprovided by MGI
Official Full Name: translocated promoter region, nuclear basket proteinprovided by MGI
Primary source: MGI:MGI:1922066
See related: Ensembl:ENSMUSG00000006005 AllianceGenome:MGI:1922066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610029M07Rik
Summary: Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in cellular response to interferon-alpha. Located in nuclear envelope; nuclear inclusion body; and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; olfactory epithelium; and vibrissa. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 19.4), placenta adult (RPKM 13.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G1; 1 63.84 cM

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (150268544..150325686)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (150392802..150449935)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	ISO Inferred from Sequence Orthology more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in RNA import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus in response to heat stress	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus in response to heat stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in nuclear matrix organization	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in nuclear pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear pore organization	ISO Inferred from Sequence Orthology more info
NOT involved_in nuclear pore organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic sister chromatid separation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic sister chromatid separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of protein stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to epidermal growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
NOT located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore nuclear basket	ISO Inferred from Sequence Orthology more info
part_of nuclear pore nuclear basket	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleoprotein TPR

Names: NPC-associated intranuclear protein; nuclear pore complex-associated protein Tpr; translocated promoter region and nuclear basket protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133780.3 → NP_598541.3 nucleoprotein TPR

See identical proteins and their annotated locations for NP_598541.3

Status: VALIDATED

Source sequence(s)

AC161432

Consensus CDS

CCDS35734.2

UniProtKB/Swiss-Prot

F6ZDS4, Q8R4A0, Q921B9

UniProtKB/TrEMBL

Q7M739

Related

ENSMUSP00000117616.3, ENSMUST00000124973.9

Conserved Domains (6) summary

pfam05483
Location:363 → 1147

SCP-1; Synaptonemal complex protein 1 (SCP-1)

TIGR04527
Location:1039 → 1124

mycoplas_twoTM; two transmembrane protein

pfam07926
Location:1112 → 1240

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

cl12013
Location:300 → 446

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl19219
Location:430 → 575

DUF342; Protein of unknown function (DUF342)

cl23720
Location:902 → 984

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

150268544..150325686

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529065.4 → XP_006529128.1 nucleoprotein TPR isoform X1

UniProtKB/TrEMBL

Q7M739

Conserved Domains (5) summary

COG1196
Location:127 → 870

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR00927
Location:1897 → 2135

2A1904; K+-dependent Na+/Ca+ exchanger

TIGR02168
Location:847 → 1687

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05109
Location:1702 → 1936

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam07926
Location:1110 → 1238

TPR_MLP1_2; TPR/MLP1/MLP2-like protein