Cd209d CD209d antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd209dprovided by MGI
Official Full Name: CD209d antigenprovided by MGI
Primary source: MGI:MGI:2157947
See related: Ensembl:ENSMUSG00000031495 AllianceGenome:MGI:2157947
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SIGNR3; SIGN-R3; mSIGNR3
Summary: Enables D-mannose binding activity and identical protein binding activity. Acts upstream of or within defense response to bacterium; endocytosis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in mammary gland adult (RPKM 6.1), subcutaneous fat pad adult (RPKM 3.3) and 4 other tissues See more
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3921824..3928548, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3871824..3878548, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway.
Title: Lactobacillus acidophilus Supplementation Exerts a Synergistic Effect on Tacrolimus Efficacy by Modulating Th17/Treg Balance in Lupus-Prone Mice via the SIGNR3 Pathway.
The sum of the data suggests that in contrast to IgG-based immune complexes boosting immune reactivity of antigen-presenting cells, secretory IgA produced during an ongoing immune response can, in addition to its known function of immune exclusion, modulate mucosal dendritic cell conditioning via specific interaction with Dectin-1 and SIGNR3.
Title: SIgA-Shigella Immune Complexes Interact with Dectin-1 and SIGNR3 to Differentially Regulate Mouse Peyer's Patch and Mesenteric Lymph Node Dendritic Cell's Responsiveness.
the SlpA/SIGNR3 interaction plays a key regulatory role in colitis.
Title: SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.
study reports the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors signature composed of Dectin-1, mannose receptor (MR)and the DC-SIGN homolog SIGNR3 expression
Title: The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.
SIGNR3 is a new differentiation marker for myeloid mononuclear cells and indicate that some dendritic cells may be replenished by monocytes.
Title: Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235833

NoName (e-PCR)
- UniSTS:493118

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-mannose binding	IBA Inferred from Biological aspect of Ancestor more info
enables D-mannose binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD209 antigen-like protein D

Names: DC-SIGN-related protein 3; DC-SIGNR3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130904.2 → NP_570974.1 CD209 antigen-like protein D

See identical proteins and their annotated locations for NP_570974.1

Status: PROVISIONAL

Source sequence(s)

AF373411

Consensus CDS

CCDS22075.1

UniProtKB/Swiss-Prot

Q8VIK4, Q91ZW8

UniProtKB/TrEMBL

Q3UW57

Related

ENSMUSP00000011445.7, ENSMUST00000011445.8

Conserved Domains (1) summary

cd03590
Location:106 → 228

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

3921824..3928548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242039.3 → XP_011240341.1 CD209 antigen-like protein D isoform X1

Conserved Domains (1) summary

cl02432
Location:106 → 186

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain