Cmip c-Maf inducing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmipprovided by MGI
Official Full Name: c-Maf inducing proteinprovided by MGI
Primary source: MGI:MGI:1921690
See related: Ensembl:ENSMUSG00000034390 AllianceGenome:MGI:1921690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4933407C03Rik; 5830471E12Rik
Summary: Acts upstream of or within in utero embryonic development. Predicted to be active in cytosol and nucleoplasm. Orthologous to human CMIP (c-Maf inducing protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 37.9), whole brain E14.5 (RPKM 37.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 63.87 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (117983758..118188245)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (117257019..117461506)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
CMIP is a negative regulator of T cell signaling.
Title: CMIP is a negative regulator of T cell signaling.
Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206.
Title: Repression of CMIP transcription by WT1 is relevant to podocyte health.
the c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway.
Title: Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis plays a critical role in Angiotensin II-induced podocyte damage.
Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Mit154 (e-PCR), detects polymorphism
- UniSTS:131359

AI464126 (e-PCR)
- UniSTS:159825

AI314065 (e-PCR)
- UniSTS:179830

NoName (e-PCR)
- UniSTS:236016

NoName (e-PCR)
- UniSTS:236017

D8Mit368 (e-PCR), detects polymorphism
- UniSTS:131582

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-Maf-inducing protein

Names: c-Mip

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163262.1 → NP_001156734.1 C-Maf-inducing protein isoform 1

See identical proteins and their annotated locations for NP_001156734.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC118207, AC121116, AK016712, AK165728, BX514237, BY243950, BY792820, CA552751

Consensus CDS

CCDS52680.1

UniProtKB/Swiss-Prot

Q69ZD2, Q8C3N2, Q8K148, Q9D486

UniProtKB/TrEMBL

B2RY70

Related

ENSMUSP00000130264.2, ENSMUST00000166750.9

Conserved Domains (3) summary

cd09293
Location:594 → 768

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:664 → 687

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00169
Location:71 → 157

PH; PH domain
NM_028941.1 → NP_083217.1 C-Maf-inducing protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC118207, AK016712, AK165728, BX514237, BY243950, CA552751

Consensus CDS

CCDS52681.1

UniProtKB/TrEMBL

B2RY70

Related

ENSMUSP00000092795.5, ENSMUST00000095172.6

Conserved Domains (2) summary

cd09293
Location:506 → 680

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:576 → 599

LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

117983758..118188245

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531434.4 → XP_006531497.1 C-Maf-inducing protein isoform X2

UniProtKB/TrEMBL

B2RY70

Conserved Domains (2) summary

cd09293
Location:518 → 692

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:588 → 611

LRR_AMN1; leucine-rich repeat [structural motif]
XM_011248527.3 → XP_011246829.3 C-Maf-inducing protein isoform X1

UniProtKB/TrEMBL

B2RY70

Conserved Domains (2) summary

cd09293
Location:546 → 685

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:581 → 604

LRR_AMN1; leucine-rich repeat [structural motif]
XM_006531436.2 → XP_006531499.1 C-Maf-inducing protein isoform X4

Conserved Domains (2) summary

cd09293
Location:442 → 581

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:477 → 500

LRR_AMN1; leucine-rich repeat [structural motif]
XM_006531435.3 → XP_006531498.1 C-Maf-inducing protein isoform X3

See identical proteins and their annotated locations for XP_006531498.1

UniProtKB/TrEMBL

B2RY70

Conserved Domains (2) summary

cd09293
Location:476 → 615

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:511 → 534

LRR_AMN1; leucine-rich repeat [structural motif]