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    Tcf4 transcription factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 21413, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tcf4provided by MGI
    Official Full Name
    transcription factor 4provided by MGI
    Primary source
    MGI:MGI:98506
    See related
    Ensembl:ENSMUSG00000053477 AllianceGenome:MGI:98506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ME2; TFE; E2-2; E2.2; ITF2; SEF2; ITF-2; SEF-2; Tcf-4; ASP-I2; ITF-2b; SEF2-1; MITF-2A; MITF-2B; bHLHb19; 5730422P05Rik
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including endothelial cell activation; negative regulation of macromolecule biosynthetic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
    Expression
    Broad expression in limb E14.5 (RPKM 8.1), frontal lobe adult (RPKM 8.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcf4 in Genome Data Viewer
    Location:
    18 E2; 18 43.23 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (69476500..69821038)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (69343429..69687967)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4402 Neighboring gene STARR-seq mESC enhancer starr_44942 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_44943 Neighboring gene STARR-positive B cell enhancer mm9_chr18:69667419-69667719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:69707648-69707831 Neighboring gene STARR-positive B cell enhancer ABC_E7607 Neighboring gene STARR-positive B cell enhancer ABC_E8724 Neighboring gene STARR-seq mESC enhancer starr_44948 Neighboring gene STARR-positive B cell enhancer ABC_E4254 Neighboring gene predicted gene, 31439 Neighboring gene STARR-seq mESC enhancer starr_44951 Neighboring gene predicted gene, 31502 Neighboring gene predicted gene, 31564

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy. Zhang L, et al. Int J Mol Med, 2016 May. PMID 26986900, Free PMC Article
    2. Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. Braun K, et al. BMC Neurosci, 2020 Nov 23. PMID 33228529, Free PMC Article
    3. Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4. Brzózka MM, et al. Behav Brain Res, 2013 Jan 15. PMID 23069005
    4. Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription. Sweatt JD. Exp Mol Med, 2013 May 3. PMID 23640545, Free PMC Article
    5. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Kaaij LT, et al. Genome Biol, 2013 May 28. PMID 23714178, Free PMC Article

    See all (248) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tcf4 dysfunction alters dorsal and ventral cortical neurogenesis in Pitt-Hopkins syndrome mouse model showing sexual dimorphism.
      Title: Tcf4 dysfunction alters dorsal and ventral cortical neurogenesis in Pitt-Hopkins syndrome mouse model showing sexual dimorphism.
    2. Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
      Title: Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
    3. Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.
      Title: Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.
    4. Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
      Title: Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
    5. Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
      Title: Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
    6. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
      Title: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
    7. MicroRNA190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4.
      Title: MicroRNA‑190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4.
    8. Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression.
      Title: Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression.
    9. Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.
      Title: Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.
    10. Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration.
      Title: Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables TFIIB-class transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endothelial cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-DNA complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of vascular endothelial growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of beta-catenin-TCF7L2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor 4
    Names
    MITF-2
    SL3-3 enhancer factor 2
    Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2)
    class A helix-loop-helix transcription factor ME2
    immunoglobulin transcription factor-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083967.1 → NP_001077436.1  transcription factor 4 isoform b

      See identical proteins and their annotated locations for NP_001077436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b).
      Source sequence(s)
      AK039181, AK047926, AK081012, BC043050, BY770794, CB247941
      Consensus CDS
      CCDS50315.1
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000110633.2, ENSMUST00000114982.8
      Conserved Domains (1) summary
      cd18945
      Location:557 → 641
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    2. NM_001361126.1 → NP_001348055.1  transcription factor 4 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC109258, AC157576, AC163095, AC169193
      Consensus CDS
      CCDS50315.1
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000144512.2, ENSMUST00000202116.4
      Conserved Domains (1) summary
      cd18945
      Location:557 → 641
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    3. NM_001361127.1 → NP_001348056.1  transcription factor 4 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC109258, AC157576, AC163095, AC169193
      Consensus CDS
      CCDS29329.1
      UniProtKB/Swiss-Prot
      Q60721, Q60722, Q62211, Q64072, Q80UE8
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000077577.7, ENSMUST00000078486.13
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    4. NM_001361128.1 → NP_001348057.1  transcription factor 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC109258, AC157576, AC163095, AC169193
      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    5. NM_001361129.1 → NP_001348058.1  transcription factor 4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC109258, AC157576, AC163095, AC169193
      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    6. NM_013685.2 → NP_038713.1  transcription factor 4 isoform a

      See identical proteins and their annotated locations for NP_038713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AK039181, AK047926, AK051958, BC043050, CB247941, U16322
      Consensus CDS
      CCDS29329.1
      UniProtKB/Swiss-Prot
      Q60721, Q60722, Q62211, Q64072, Q80UE8
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000110636.4, ENSMUST00000114985.10
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      69476500..69821038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317857.2 → XP_017173346.1  transcription factor 4 isoform X5

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:557 → 641
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    2. XM_030250374.1 → XP_030106234.1  transcription factor 4 isoform X3

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    3. XM_017317854.2 → XP_017173343.1  transcription factor 4 isoform X2

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    4. XM_030250376.1 → XP_030106236.1  transcription factor 4 isoform X6

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:556 → 640
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    5. XM_030250375.1 → XP_030106235.1  transcription factor 4 isoform X4

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:559 → 643
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    6. XM_030250384.1 → XP_030106244.1  transcription factor 4 isoform X15

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:453 → 537
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    7. XM_006525753.4 → XP_006525816.1  transcription factor 4 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YUK1, A0A0J9YUZ0
      Related
      ENSMUSP00000144209.2, ENSMUST00000201781.4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    8. XM_030250382.1 → XP_030106242.1  transcription factor 4 isoform X12

      UniProtKB/TrEMBL
      A0A0J9YUK1, A0A0J9YUP9
      Related
      ENSMUSP00000144285.2, ENSMUST00000201631.4
      Conserved Domains (1) summary
      cd18945
      Location:533 → 617
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    9. XM_030250381.1 → XP_030106241.1  transcription factor 4 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YUK1
      Conserved Domains (1) summary
      cd18945
      Location:536 → 620
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    10. XM_036161052.1 → XP_036016945.1  transcription factor 4 isoform X13

      UniProtKB/TrEMBL
      A0A0J9YUK1, A0A0J9YVG2
      Related
      ENSMUSP00000144646.2, ENSMUST00000202354.4
      Conserved Domains (1) summary
      cd18945
      Location:532 → 616
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    11. XM_017317859.2 → XP_017173348.1  transcription factor 4 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YUK1
      Conserved Domains (1) summary
      cd18945
      Location:536 → 620
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    12. XM_030250386.1 → XP_030106246.1  transcription factor 4 isoform X15

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:453 → 537
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    13. XM_036161051.1 → XP_036016944.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:556 → 640
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    14. XM_030250377.2 → XP_030106237.1  transcription factor 4 isoform X6

      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000143987.2, ENSMUST00000202772.4
      Conserved Domains (1) summary
      cd18945
      Location:556 → 640
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    15. XM_030250373.2 → XP_030106233.1  transcription factor 4 isoform X2

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    16. XM_036161049.1 → XP_036016942.1  transcription factor 4 isoform X1

      UniProtKB/Swiss-Prot
      Q60721, Q60722, Q62211, Q64072, Q80UE8
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000144670.2, ENSMUST00000202610.4
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    17. XM_006525746.5 → XP_006525809.1  transcription factor 4 isoform X1

      See identical proteins and their annotated locations for XP_006525809.1

      UniProtKB/Swiss-Prot
      Q60721, Q60722, Q62211, Q64072, Q80UE8
      UniProtKB/TrEMBL
      Q8CE98
      Related
      ENSMUSP00000110631.3, ENSMUST00000114980.8
      Conserved Domains (1) summary
      cd18945
      Location:561 → 645
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    18. XM_006525752.4 → XP_006525815.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:556 → 640
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    19. XM_006525748.4 → XP_006525811.1  transcription factor 4 isoform X2

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:560 → 644
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    20. XM_006525751.5 → XP_006525814.1  transcription factor 4 isoform X6

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:556 → 640
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    21. XM_017317856.3 → XP_017173345.1  transcription factor 4 isoform X4

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:559 → 643
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    22. XM_017317858.2 → XP_017173347.1  transcription factor 4 isoform X8

      UniProtKB/TrEMBL
      Q8CE98
      Conserved Domains (1) summary
      cd18945
      Location:555 → 639
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    23. XM_036161055.1 → XP_036016948.1  transcription factor 4 isoform X16

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Related
      ENSMUSP00000143875.2, ENSMUST00000202458.4
      Conserved Domains (1) summary
      cd18945
      Location:449 → 533
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    24. XM_030250379.1 → XP_030106239.1  transcription factor 4 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YUK1, A0A0J9YUZ0
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    25. XM_030250378.2 → XP_030106238.1  transcription factor 4 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YUK1, A0A0J9YUZ0
      Related
      ENSMUSP00000144407.2, ENSMUST00000202435.4
      Conserved Domains (1) summary
      cd18945
      Location:537 → 621
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    26. XM_030250380.2 → XP_030106240.1  transcription factor 4 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YUK1
      Conserved Domains (1) summary
      cd18945
      Location:536 → 620
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    27. XM_030250387.1 → XP_030106247.1  transcription factor 4 isoform X15

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:453 → 537
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    28. XM_036161056.1 → XP_036016949.1  transcription factor 4 isoform X16

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:449 → 533
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    29. XM_036161053.1 → XP_036016946.1  transcription factor 4 isoform X14

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:485 → 569
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    30. XM_017317863.3 → XP_017173352.1  transcription factor 4 isoform X17

      UniProtKB/TrEMBL
      A0A0J9YTU7, A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    31. XM_017317861.3 → XP_017173350.1  transcription factor 4 isoform X19

      UniProtKB/TrEMBL
      A0A0J9YTW1, A0A0J9YUG4
      Related
      ENSMUSP00000144169.2, ENSMUST00000201094.4
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    32. XM_030250390.2 → XP_030106250.1  transcription factor 4 isoform X17

      UniProtKB/TrEMBL
      A0A0J9YTU7, A0A0J9YTW1
      Related
      ENSMUSP00000144273.2, ENSMUST00000201205.4
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    33. XM_030250392.2 → XP_030106252.1  transcription factor 4 isoform X19

      UniProtKB/TrEMBL
      A0A0J9YTW1, A0A0J9YUG4
      Related
      ENSMUSP00000143950.2, ENSMUST00000201410.4
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    34. XM_017317860.2 → XP_017173349.1  transcription factor 4 isoform X17

      UniProtKB/TrEMBL
      A0A0J9YTU7, A0A0J9YTW1
      Related
      ENSMUSP00000143857.2, ENSMUST00000202937.4
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    35. XM_030250393.2 → XP_030106253.1  transcription factor 4 isoform X19

      UniProtKB/TrEMBL
      A0A0J9YTW1, A0A0J9YUG4
      Related
      ENSMUSP00000144219.2, ENSMUST00000202477.4
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    36. XM_006525759.4 → XP_006525822.1  transcription factor 4 isoform X17

      See identical proteins and their annotated locations for XP_006525822.1

      UniProtKB/TrEMBL
      A0A0J9YTU7, A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:432 → 516
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    37. XM_030250394.2 → XP_030106254.1  transcription factor 4 isoform X19

      UniProtKB/TrEMBL
      A0A0J9YTW1, A0A0J9YUG4
      Related
      ENSMUSP00000144647.2, ENSMUST00000202057.4
      Conserved Domains (1) summary
      cd18945
      Location:428 → 512
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    38. XM_036161057.1 → XP_036016950.1  transcription factor 4 isoform X18

      UniProtKB/TrEMBL
      A0A0J9YTW1
      Conserved Domains (1) summary
      cd18945
      Location:431 → 515
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    39. XM_006525760.4 → XP_006525823.1  transcription factor 4 isoform X20

      See identical proteins and their annotated locations for XP_006525823.1

      UniProtKB/TrEMBL
      A0A0J9YTR9, Q91XK1
      Related
      ENSMUSP00000110629.3, ENSMUST00000114978.9
      Conserved Domains (1) summary
      cd18945
      Location:402 → 486
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    40. XM_006525762.4 → XP_006525825.1  transcription factor 4 isoform X22

      See identical proteins and their annotated locations for XP_006525825.1

      UniProtKB/TrEMBL
      A0A0J9YTR9, Q91YV0
      Related
      ENSMUSP00000110628.2, ENSMUST00000114977.5
      Conserved Domains (1) summary
      cd18945
      Location:398 → 482
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    41. XM_006525766.4 → XP_006525829.1  transcription factor 4 isoform X21

      UniProtKB/TrEMBL
      A0A0J9YTR9
      Conserved Domains (1) summary
      cd18945
      Location:401 → 485
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    42. XM_030250397.1 → XP_030106257.1  transcription factor 4 isoform X23

      UniProtKB/TrEMBL
      A0A0J9YTR9
      Conserved Domains (1) summary
      cd18945
      Location:397 → 481
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    RNA

    1. XR_004939838.1 RNA Sequence

    2. XR_004939839.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60722.1 GenPept UniProtKB/Swiss-Prot:Q60722

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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