mao monoamine oxidase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: maoprovided by ZNC
Official Full Name: monoamine oxidaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040329-3
See related: Ensembl:ENSDARG00000023712 AllianceGenome:ZFIN:ZDB-GENE-040329-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: moa; maob; Z-MAO; zgc:85761; wu:fb68b05; wu:fo76d11; wu:fq38g06
Summary: Enables primary methylamine oxidase activity. Involved in cellular biogenic amine catabolic process. Acts upstream of or within social behavior; startle response; and swimming behavior. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in brain; digestive system; gill; heart; and neurons. Human ortholog(s) of this gene implicated in Brunner Syndrome; alcohol use disorder; autism spectrum disorder; neurodegenerative disease (multiple); and panic disorder. Orthologous to several human genes including MAOB (monoamine oxidase B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (33660964..33725972, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (33851779..33916787, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of Chronic Unpredictable Stress-Persuaded Increased Monoamine Oxidase Activity by Taurine Promotes Significant Neuroprotection in Zebrafish Brain.
Title: Suppression of Chronic Unpredictable Stress-Persuaded Increased Monoamine Oxidase Activity by Taurine Promotes Significant Neuroprotection in Zebrafish Brain.
Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish.
Title: Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish.
Conspecific alarm substance acutely elicits fear-induced aggression and decreases brain Z-MAO activity in WT and leo zebrafish populations. However, the reduced aggressive behavior could be associated to a decreased locomotion following the chronic exposure, which did not change Z-MAO activity.
Title: Modulatory role of conspecific alarm substance on aggression and brain monoamine oxidase activity in two zebrafish populations.
Zebrafish MAO (zMAO) exhibits functional properties similar to human hMAO A as well as exhibits its own unique behavior.
Title: Catalytic and inhibitor binding properties of zebrafish monoamine oxidase (zMAO): comparisons with human MAO A and MAO B.
expression, purification & characterization of zebrafish monoamine oxidase (zMAO) using Pichia pastoris expression system is described; zMAO possesses little differential sensitivity to acetylenic inhibitors than exhibited by either human MAO A & MAO B
Title: Expression of zebrafish (Danio rerio) monoamine oxidase (MAO) in Pichia pastoris: purification and comparison with human MAO A and MAO B.
this study confirm the presence of functionally active MAO in zebrafish brain and other tissues and characterize the neural systems that express MAO and areas of intense activity in the brain.
Title: Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio).

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General gene information

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Markers

fb68b05 (e-PCR)
- UniSTS:189080

fj79b12.y1 (e-PCR)
- UniSTS:199919

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aliphatic amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables monoamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables monoamine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables primary methylamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables primary methylamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables primary methylamine oxidase activity	IEA Inferred from Electronic Annotation more info
enables primary methylamine oxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within biogenic amine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in biogenic amine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within catecholamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amine oxidase [flavin-containing]

Names: amine oxidase

NP_997992.2

EC 1.4.3.21

EC 1.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212827.3 → NP_997992.2 amine oxidase [flavin-containing]

See identical proteins and their annotated locations for NP_997992.2

Status: VALIDATED

Source sequence(s)

BX572627

UniProtKB/Swiss-Prot

Q6NSN2, Q804D6

Related

ENSDARP00000032834.6, ENSDART00000028225.7

Conserved Domains (2) summary

pfam01593
Location:15 → 452

Amino_oxidase; Flavin containing amine oxidoreductase

pfam13450
Location:10 → 76

NAD_binding_8; NAD(P)-binding Rossmann-like domain