sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sgcdprovided by ZNC
Official Full Name: sarcoglycan, delta (dystrophin-associated glycoprotein)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3684
See related: Ensembl:ENSDARG00000098573 AllianceGenome:ZFIN:ZDB-GENE-030131-3684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc49e11; zgc:110649
Summary: Acts upstream of or within several processes, including heart contraction; somatic muscle development; and swim bladder inflation. Located in sarcolemma. Is expressed in several structures, including brain; cardiovascular system; musculature system; retina; and swim bladder. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2F; dilated cardiomyopathy 1L; and muscular dystrophy. Orthologous to human SGCD (sarcoglycan delta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (35643013..36052898, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (35617273..36006447, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

delta-sarcoglycan plays an important role in early heart and muscle development.
Title: Delta-sarcoglycan is necessary for early heart and muscle development in zebrafish.
Protein required for muscle organization.
Title: Delta-sarcoglycan is required for early zebrafish muscle organization.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swim bladder inflation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of sarcoglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sarcoglycan complex	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta-sarcoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001816.4 → NP_001001816.2 delta-sarcoglycan

Status: VALIDATED

Source sequence(s)

BX294656, CR388143, EB793402

UniProtKB/TrEMBL

A0A0R4IBS6, A0A8M1MZM5

Related

ENSDARP00000131999.1, ENSDART00000172245.2

Conserved Domains (1) summary

pfam04790
Location:26 → 279

Sarcoglycan_1; Sarcoglycan complex subunit protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

35643013..36052898 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068215786.1 → XP_068071887.1 delta-sarcoglycan isoform X2
XM_009295594.4 → XP_009293869.1 delta-sarcoglycan isoform X3

UniProtKB/TrEMBL

A0A8M3AU43

Related

ENSDARP00000154367.1, ENSDART00000180840.1

Conserved Domains (1) summary

pfam04790
Location:27 → 275

Sarcoglycan_1; Sarcoglycan complex subunit protein
XM_068215785.1 → XP_068071886.1 delta-sarcoglycan isoform X1