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    mical3b microtubule associated monooxygenase, calponin and LIM domain containing 3b [ Danio rerio (zebrafish) ]

    Gene ID: 566850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mical3bprovided by ZNC
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 3bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050211-1
    See related
    Ensembl:ENSDARG00000094732 AllianceGenome:ZFIN:ZDB-GENE-050211-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MICAL-3B; im:7143388; si:dkeyp-27e10.1; si:dkey-153k10.11
    Summary
    Predicted to enable FAD binding activity; actin binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in actin filament depolymerization. Predicted to act upstream of or within exocytosis. Predicted to be located in nucleus. Is expressed in floor plate; hindbrain nucleus; octaval nerve motor nucleus; octaval nerve sensory nucleus; and spinal cord. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mical3b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (9724233..9765226, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (9723309..9763915, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2b Neighboring gene tetraspanin 9b Neighboring gene uncharacterized LOC103910414 Neighboring gene SVOP-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of mical family genes in zebrafish. Xue Y, et al. J Genet Genomics, 2010 Oct. PMID 21035094
    2. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Liu LY, et al. Dis Model Mech, 2013 Sep. PMID 23813869, Free PMC Article
    3. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein-methionine sulfoxide oxidase mical3b
    Names
    molecule interacting with CasL 3b
    molecule interacting with CasL protein 3B
    NP_001340804.1
    XP_009298467.1
    XP_009298470.1
    XP_017210768.1
    XP_021330889.1
    XP_021330890.1
    XP_021330891.1
    XP_021330892.1
    XP_021330893.1
    XP_021330894.1
    XP_068075807.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353875.1 → NP_001340804.1  protein-methionine sulfoxide oxidase mical3b

      Status: VALIDATED

      Source sequence(s)
      BX649444, BX901962
      UniProtKB/TrEMBL
      A0A8M9Q8P9
      Related
      ENSDARP00000133311.2, ENSDART00000164328.2
      Conserved Domains (5) summary
      cd09439
      Location:756 → 810
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      COG0446
      Location:42 → 118
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1497 → 1648
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      9724233..9765226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475217.2 → XP_021330892.1  protein-methionine sulfoxide oxidase mical3b isoform X6

      UniProtKB/TrEMBL
      A0A8M9PHR6, A0A8M9Q4D5
      Conserved Domains (5) summary
      cd09439
      Location:756 → 810
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      COG0446
      Location:42 → 118
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1497 → 1684
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    2. XM_021475215.2 → XP_021330890.1  protein-methionine sulfoxide oxidase mical3b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PES7, A0A8M9PRL3, A0A8M9QBR6
      Conserved Domains (4) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1533 → 1720
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    3. XM_021475216.2 → XP_021330891.1  protein-methionine sulfoxide oxidase mical3b isoform X4

      UniProtKB/TrEMBL
      A0A8M9PXR3, A0A8M9Q689
      Conserved Domains (5) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      COG0446
      Location:42 → 118
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1508 → 1695
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    4. XM_009300195.4 → XP_009298470.1  protein-methionine sulfoxide oxidase mical3b isoform X7

      UniProtKB/TrEMBL
      A0A8M3ARC5, A0A8M9PET2
      Conserved Domains (3) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1530 → 1668
      DUF3585; Protein of unknown function (DUF3585)

    5. XM_068219706.1 → XP_068075807.1  protein-methionine sulfoxide oxidase mical3b isoform X3

      UniProtKB/TrEMBL
      A0A8M9PES7

    6. XM_017355279.3 → XP_017210768.1  protein-methionine sulfoxide oxidase mical3b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PES7, A0A8M9Q0Z6
      Conserved Domains (4) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1534 → 1721
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    7. XM_009300192.4 → XP_009298467.1  protein-methionine sulfoxide oxidase mical3b isoform X5

      See identical proteins and their annotated locations for XP_009298467.1

      UniProtKB/TrEMBL
      A0A8M3AYP9, A0A8M9Q8P9
      Related
      ENSDARP00000122943.2, ENSDART00000147699.4
      Conserved Domains (3) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1530 → 1685
      DUF3585; Protein of unknown function (DUF3585)

    8. XM_021475214.2 → XP_021330889.1  protein-methionine sulfoxide oxidase mical3b isoform X1

      UniProtKB/TrEMBL
      A0A8M9PES7, A0A8M9Q0Z6
      Conserved Domains (4) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1534 → 1721
      DUF3585; Protein of unknown function (DUF3585)
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    9. XM_021475218.2 → XP_021330893.1  protein-methionine sulfoxide oxidase mical3b isoform X8

      UniProtKB/TrEMBL
      A0A8M9PRL9, A0A8M9PV05
      Conserved Domains (3) summary
      cd09439
      Location:630 → 684
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:355 → 450
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1371 → 1558
      DUF3585; Protein of unknown function (DUF3585)

    10. XM_021475219.2 → XP_021330894.1  protein-methionine sulfoxide oxidase mical3b isoform X9

      UniProtKB/TrEMBL
      A0A8M9Q100
      Conserved Domains (4) summary
      cd09439
      Location:793 → 847
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      COG0446
      Location:42 → 118
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      pfam00307
      Location:518 → 613
      CH; Calponin homology (CH) domain
      cl27552
      Location:86 → 140
      FAD_binding_3; FAD binding domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394550.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      280063..312358 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395230.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      148168..188974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QWK4.2 GenPept UniProtKB/Swiss-Prot:F1QWK4

    Gene LinkOut

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    Research Materials