kmt2ba lysine (K)-specific methyltransferase 2Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kmt2baprovided by ZNC
Official Full Name: lysine (K)-specific methyltransferase 2Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-376
See related: Ensembl:ENSDARG00000062962 AllianceGenome:ZFIN:ZDB-GENE-060503-376
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mll4a; si:rp71-15k1.2
Summary: Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization and methylation. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; colorectal adenocarcinoma; dystonia 28, childhood-onset; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (9232678..9275240)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (9313048..9356315)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc22b10.x1 (e-PCR)
- UniSTS:193080

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone H3K4 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase 2B

Names: myeloid/lymphoid or mixed-lineage leukemia 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

9232678..9275240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_684255.10 → XP_689347.5 histone-lysine N-methyltransferase 2B isoform X3

UniProtKB/TrEMBL

A0A8M2B633, A0A8N7TDQ0

Related

ENSDARP00000113465.2, ENSDART00000136957.3

Conserved Domains (7) summary

cd05493
Location:1187 → 1334

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00317
Location:2725 → 2845

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:2677 → 2863

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam02008
Location:780 → 823

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:1540 → 1586

FYRN; F/Y-rich N-terminus

cl02651
Location:2561 → 2646

FYRC; F/Y rich C-terminus

cl22851
Location:1389 → 1492

PHD_SF; PHD finger superfamily
XM_068215240.1 → XP_068071341.1 histone-lysine N-methyltransferase 2B isoform X1

UniProtKB/TrEMBL

A0A8M2B633

Related

ENSDARP00000147918.1, ENSDART00000190617.1
XM_005159485.5 → XP_005159542.1 histone-lysine N-methyltransferase 2B isoform X4

UniProtKB/TrEMBL

A0A8M2B633, A0A8M2B683

Conserved Domains (7) summary

cd05493
Location:1186 → 1333

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00317
Location:2724 → 2844

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:2676 → 2862

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam02008
Location:780 → 823

zf-CXXC; CXXC zinc finger domain

pfam05964
Location:1539 → 1585

FYRN; F/Y-rich N-terminus

cl02651
Location:2560 → 2645

FYRC; F/Y rich C-terminus

cl22851
Location:1388 → 1491

PHD_SF; PHD finger superfamily
XM_068215241.1 → XP_068071342.1 histone-lysine N-methyltransferase 2B isoform X2

UniProtKB/TrEMBL

A0A8M2B633