elp1 elongator acetyltransferase complex subunit 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elp1provided by ZNC
Official Full Name: elongator acetyltransferase complex subunit 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-071116-7
See related: Ensembl:ENSDARG00000094204 AllianceGenome:ZFIN:ZDB-GENE-071116-7
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ikbkap; ikbkapl
Summary: Predicted to enable tRNA binding activity. Acts upstream of or within enteric nervous system development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol. Is expressed in intestinal epithelium. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; kyphosis; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (6245942..6286980, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (5939108..5980143, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of IKBKAP contributed to Hirschsprung disease-like phenotype as demonstrated by functional analysis in zebrafish embryos.
Title: Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Ndufb11 (e-PCR), detects polymorphism
- UniSTS:498527

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA wobble uridine modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of elongator holoenzyme complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongator complex protein 1

Names: IKAP; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

6245942..6286980 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_684442.9 → XP_689534.5 elongator complex protein 1

UniProtKB/TrEMBL

A0A0R4IJ07, A0A8N7TER5

Related

ENSDARP00000135682.1, ENSDART00000168174.2

Conserved Domains (3) summary

COG5290
Location:71 → 1255

COG5290; IkappaB kinase complex, IKAP component [Transcription]

sd00008
Location:962 → 993

TPR_YbbN; TPR repeat [structural motif]

pfam04762
Location:1 → 934

IKI3; IKI3 family