med14 mediator complex subunit 14 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: med14provided by ZNC
Official Full Name: mediator complex subunit 14provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8867
See related: Ensembl:ENSDARG00000009953 AllianceGenome:ZFIN:ZDB-GENE-030131-8867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: EXLM1; crsp2; crsp150; trap170; wu:fd21c05; wu:fk28h11
Summary: Predicted to enable transcription coregulator activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; regulation of T cell differentiation in thymus; and ventricular system development. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in head and trunk. Orthologous to human MED14 (mediator complex subunit 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (34397826..34424015)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (34588627..34614830)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transplantation experiments demonstrated that med14 and brg1 are required directly in neural crest cells. Analysis of med14; brg1 double mutant embryos suggested the existence of strong genetic interaction between members of Mediator and BAF complexes.
Title: Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mediator of RNA polymerase II transcription subunit 14

Names: cofactor required for Sp1 transcriptional activation, subunit 2; log; logelei

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212765.2 → NP_997930.2 mediator of RNA polymerase II transcription subunit 14

Status: VALIDATED

Source sequence(s)

BX294189

UniProtKB/TrEMBL

A0A8M1PFL7

Conserved Domains (2) summary

pfam08638
Location:36 → 223

Med14; Mediator complex subunit MED14

pfam12316
Location:962 → 1149

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

34397826..34424015

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167821.5 → XP_005167878.1 mediator of RNA polymerase II transcription subunit 14 isoform X1

UniProtKB/TrEMBL

A0A8M2BFA2, F1R9C9

Related

ENSDARP00000010465.7, ENSDART00000011304.9

Conserved Domains (2) summary

pfam08638
Location:36 → 223

Med14; Mediator complex subunit MED14

pfam12316
Location:962 → 1148

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
XM_005167822.4 → XP_005167879.1 mediator of RNA polymerase II transcription subunit 14 isoform X2

UniProtKB/TrEMBL

A0A8M2BFA7, E9QDB5

Related

ENSDARP00000123079.1, ENSDART00000146314.2

Conserved Domains (2) summary

pfam08638
Location:36 → 223

Med14; Mediator complex subunit MED14

pfam11235
Location:987 → 1125

Med25_SD1; Mediator complex subunit 25 synapsin 1