igfbp1a insulin-like growth factor binding protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igfbp1aprovided by ZNC
Official Full Name: insulin-like growth factor binding protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021231-1
See related: Ensembl:ENSDARG00000099351 AllianceGenome:ZFIN:ZDB-GENE-021231-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb656; igfbp1; IGFBP-1
Summary: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Acts upstream of or within negative regulation of cell population proliferation; regeneration; and response to hypoxia. Located in cytoplasm. Is expressed in several structures, including adaxial cell; brain; cardiovascular system; digestive system; and gonad. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (6808774..6812616, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (6818827..6822654, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1
Title: Hypoxia impairs primordial germ cell migration in zebrafish (Danio rerio) embryos.
TGE duplicated IGFBP-1 may provide additional flexibility in fine-tuning insulin-like growth factor signaling activities under hypoxia and other catabolic conditions.
Title: Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish.
HIF-1 mediates hypoxia-induced IGFBP-1 gene expression in early development by selectively interacting with the hypoxia response elements and its adjacent HIF-1 ancillary sequence.
Title: Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression.
The insulin-like growth factor binding protein 1 (29-31kDa)is similarities to mammalian.
Title: Insulin-like growth factor signaling in fish.

Submit: New GeneRIF Correction

General gene information

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Markers

AI585033 (e-PCR)
- UniSTS:206210

fb68e07 (e-PCR), detects polymorphism
- UniSTS:189087

fb04h01.y1 (e-PCR)
- UniSTS:189872

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 1a

Names: insulin-like growth factor binding protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173283.4 → NP_775390.3 insulin-like growth factor-binding protein 1a precursor

Status: VALIDATED

Source sequence(s)

CR926131

UniProtKB/TrEMBL

A0A0K0WSG9, A0A0R4IK51, Q8JHX6, Q90YJ7

Related

ENSDARP00000135671.1, ENSDART00000170934.2

Conserved Domains (2) summary

smart00121
Location:34 → 111

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:181 → 256

Thyroglobulin_1; Thyroglobulin type-1 repeat